Nature 308, 149 - 153 (08 March 1984); doi:10.1038/308149a0

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

Stephen M. Hedrick^*‡, David I. Cohen^*†, Ellen A. Nielsen^* & Mark M. Davis^*†‡

^*Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20205, USA
^†Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California 94305, USA
^‡Present addresses: Department of Biology, University of California at San Diego, La Jolla, California 92093, USA (S.M.H.); Stanford University School of Medicine (M.M.D.).

Of 10 distinct cloned DNA copies of mRNAs expressed in T lymphocytes but not in B lymphocytes and associated with membrane-bound polysomes, one hybridizes to a region of the genome that has rearranged in a T-cell lymphoma and several T-cell hybridomas. These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes.

References

1.	Katz, D. H. Lymphocyte Differentiation, Recognition and Regulation, 152−187 (Academic, New York, 1977).
2.	Melief, C. J. M., deWaal, L. P., van der Meulen, M. Y., Melvold, R. W. & Kohn, H. I. J. exp. Med. 151, 993−1013 (1980). | Article | PubMed | ISI | ChemPort |
3.	von Boehmer, H. & Haas, W. Immun. Rev. 54, 27−56 (1981). | PubMed | ChemPort |
4.	Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701−702 (1974). | PubMed | ISI | ChemPort |
5.	Zinkernagel, R. M. & Doherty, P. C. Adv. Immun. 27, 51−177 (1979). | PubMed | ChemPort |
6.	Fink, P. J. & Bevan, M. J. exp. Med. 148, 776−785 (1978). | Article | PubMed |
7.	Warr, G. W., DeLuca, D. & Marchalonis, J. Proc. natn. Acad. Sci. U.S.A. 73, 2476−2480 (1976). | ChemPort |
8.	Kronenberg, M., Davis, M. M., Early, P. W., Hood, L. E. & Watson, J. D. J. exp. Med. 152, 1745−1761 (1980). | Article | PubMed | ISI | ChemPort |
9.	Nakanishi, K. et al. Proc. natn. Acad. Sci. U.S.A. 79, 6984−6988 (1982). | ChemPort |
10.	Kurosawa, Y. H. et al. Nature 290, 565−570 (1981). | PubMed | ISI | ChemPort |
11.	Kronenberg, M. et al. J. exp. Med. 158, 210−227 (1983). | Article | PubMed | ISI | ChemPort |
12.	Kraig, E. et al. J. exp. Med. 158, 192−209 (1983). | Article | PubMed | ISI | ChemPort |
13.	Eichmann, K. & Rajewsky, K. Eur. J. Immun. 5, 661−666 (1975). | ISI | ChemPort |
14.	Binz, H. & Wigzell, H. J. exp. Med. 142, 197−211 (1975). | Article | PubMed | ISI | ChemPort |
15.	Augustin, A. A., Julius, M. H., Cosenza, H. & Matsunaga, T. in Regulatory T Lymphocytes (eds Pernis, B. & Vogel, H. J.) 171−184 (Academic, New York, 1980).
16.	Berek, C., Taylor, B. A. & Eichmann, K. J. exp. Med. 144, 1164−1175 (1976). | Article | PubMed | ISI | ChemPort |
17.	Strassman, G., Lifshitz, R. & Mozes, E. J. exp. Med. 152, 1448−1452 (1980). | Article | PubMed |
18.	Infante, A. J., Infante, P. D., Gilles, S. & Fathman, C. G. J. exp. Med. 155, 1100−1107 (1982). | Article | PubMed | ISI | ChemPort |
19.	Allison, J. P., MacIntyre, B. W. & Block, D. J. Immun. 129, 2293−2300 (1982). | PubMed | ISI | ChemPort |
20.	Haskins, K. et al. J. exp. med. 157, 1149−1169 (1983). | Article | PubMed | ISI | ChemPort |
21.	Meuer, S. C. et al. Nature 303, 808−810 (1983). | Article | PubMed | ISI | ChemPort |
22.	Samuelson, L. E. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6972−6976 (1983). | ChemPort |
23.	McIntyre, B. W. & Allison, J. P. Cell 34, 739−746 (1983). | Article | PubMed | ISI | ChemPort |
24.	Acuto, O. et al. Cell 34, 717−726 (1983). | Article | PubMed | ISI | ChemPort |
25.	Heber-Katz, E. et al. J. exp. Med. 155, 1086−1099 (1982). | Article | PubMed | ChemPort |
26.	Hedrick, S. M. et al. Cell 30, 141−152 (1982). | Article | PubMed | ISI | ChemPort |
27.	Blobel, G. & Dobberstein, B. J. Cell Biol. 67, 835−851 (1975). | Article | PubMed | ISI | ChemPort |
28.	Davis, M. M., Cohen, D. I., Nielsen, E. A., DeFranco, A. D. & Paul, W. E. UCLA Symp. 24, 215−220 (1982). | ISI |
29.	Mechler, B. & Rabbitts, T. H. J. Cell Biol. 88, 29−36 (1981). | Article | PubMed | ISI | ChemPort |
30.	Davis, M. M. et al. Proc. natn. Acad. Sci. U.S.A. (in the press).
31.	Bishop, J. O., Morton, J. G., Rosbash, M. & Richardson, M. Nature 250, 199−204 (1974). | PubMed | ISI | ChemPort |
32.	Pearson, W. R., Davidson, E. H. & Britten, R. J. Nucleic Acids Res. 4, 1727−1735 (1977). | PubMed | ISI | ChemPort |
33.	Lewin, B. in Gene Expression Vol. 2, 2nd edn (Wiley, New York, 1980).
34.	Meyuhas, O. & Perry, R. P. Cell 16, 139−148 (1979). | Article | PubMed | ISI | ChemPort |
35.	Milner, R. J. & Sutcliffe, J. G. Nucleic Acids Res. 11, 5497−5520 (1983). | PubMed | ISI | ChemPort |
36.	Sargent, T. & Dawid, I. Science 222, 135−139 (1983). | PubMed | ChemPort |
37.	Hanahan, D. & Meselson, M. Gene 10, 63−67 (1980). | Article | PubMed | ISI | ChemPort |
38.	Ish-Horowicz, D. & Burke, J. F. Nucleic Acids Res. 9, 2989−2998 (1981). | PubMed | ChemPort |
39.	Moriuchi, T., Chang, H. C., Denome, R. & Silver, J. Nature 301, 80−82 (1983). | Article | PubMed | ISI | ChemPort |
40.	Dworkin, M. B. & David, I. B. Devl Biol. 76, 435−448 (1980). | ChemPort |
41.	Crampton, J., Humphries, S., Woods, D. & Williamson, R. Nucleic Acids Res. 8, 6007−6017 (1980). | PubMed | ISI | ChemPort |
42.	Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I. & Davis, M. M. Nature 308, 153−158 (1984). | Article | PubMed | ISI | ChemPort |
43.	Mather, E. L. et al. Cell 23, 369−378 (1981). | Article | PubMed | ISI | ChemPort |
44.	Zimmerman, C. R., Orr, W. C., Leclerc, R. F., Barnard, E. C. & Timberlake, W. E. Cell 23, 709−715 (1980). | Article |
45.	Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P. & Cole, M. D. Cell 31, 443−452 (1982). | Article | PubMed | ChemPort |
46.	Mushinski, J. F. et al. Proc. natn. Acad. Sci. U.S.A. 77, 7405−7409 (1980). | ChemPort |
47.	Britten, R. J., Graham, D. E. & Neufeld, B. R. Meth. Enzym. 29, 363−418 (1974). | Article | PubMed | ChemPort |
48.	Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1982).
49.	Glimcher, L. H. & Sherach, E. M. J. exp. Med. 156, 640−645 (1982). | Article | PubMed | ISI | ChemPort |