Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

An interleukin 1 like factor stimulates bone resorption in vitro

Nature volume 306, pages 378–380 (1983)Cite this article

Abstract

Many activities are now ascribed to the monokine interleukin 11 including enhancement of immune responses, stimulation of thymocyte proliferation2, activation of B cells3, stimulation of proteinase and prostaglandin production by connective tissue cells4, stimulation of the production of acute phase proteins5, induction of fever6 and the induction of neutrophilia7. These activities were thought to be due to various different factors, but are now considered probably due to very similar, if not identical, molecules8–11. The term interleukin 1 (IL-1) was coined to describe the factor released by monocyte/macrophages which acts on T and B lymphocytes. Only after this definition had been accepted was it shown that target cells other than lymphocytes were affected by IL-1. Products of human blood monocytes (mononuclear cell factor, MCF) have been implicated in the pathogenesis of inflammatory diseases such as rheumatoid arthritis and periodontal disease12,13. Bone resorption is often a feature of such diseases, and monocytes are frequently found at sites of localized bone resorption. Preliminary experiments with monocyte-conditioned medium indicated that MCF could stimulate bone resorption14. We therefore undertook this study to verify these observations and to determine whether purified IL-1 could stimulate connective tissue breakdown in vitro.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Oppenheim, J. J. & Gery, I. Immun. Today. 3, 113–119 (1982).

    Article  CAS  PubMed  Google Scholar 

  2. Gery, I., Gershon, R. K. & Waksman, B. H. J. exp. Med. 136, 128–142 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wood, D. D. & Gaul, S. L. J. Immun. 113, 925–933 (1974).

    CAS  PubMed  Google Scholar 

  4. Dayer, J. M., Stephenson, M. L., Schmidt, E., Karge, W. & Krane, S. M. FEBS Lett. 124, 253–256(1981).

    Article  CAS  PubMed  Google Scholar 

  5. Wannenmacher, R. W. et al. Endocrinology 96, 651–661 (1975).

    Article  Google Scholar 

  6. Dinarello, C. A., Goldin, N. P. & Wolff, S. M. J. exp. Med. 139, 1396–1381 (1974).

    Article  Google Scholar 

  7. Merriman, C. R., Pulliam, L. A. & Kampschmidt, R. A. Proc. Soc. exp. Biol. Med. 154, 224–227 (1977).

    Article  CAS  PubMed  Google Scholar 

  8. Wood, D. D. J. Immun. 123, 2400–2407 (1979).

    CAS  PubMed  Google Scholar 

  9. Mizel, S. B., Dayer, J. M., Krane, S. M. & Mergenhagen, S. E. Proc. natn. Acad. Sci. U.S.A. 78, 2474–2477 (1981).

    Article  ADS  CAS  Google Scholar 

  10. Sztein, M. B. et al. Cell. Immun. 63, 164–176 (1981).

    Article  CAS  Google Scholar 

  11. Murphy, P. A., Simon, P. L. & Willoughby, W. F. J. Immun. 124, 2498–2501 (1980).

    CAS  PubMed  Google Scholar 

  12. Krane, S. M. Annls. rheum Dis. 40, 433–448 (1981).

    Article  CAS  Google Scholar 

  13. Russell, R. G. G., McGuire, M. K. B., Meats, J. E., Ebsworth, N. M. & Beresford, J. Scand. J. Rheum. Suppl. 40, 75–87 (1981).

    Article  CAS  Google Scholar 

  14. Gowen, M., Meikle, M. C. & Reynolds, J. J. Biochim. biophys. Acta. 762, 471–474 (1983).

    Article  CAS  PubMed  Google Scholar 

  15. Wood, D. D. & Cameron, P. M. Cell Immun. 21 133–145(1976).

    Article  CAS  Google Scholar 

  16. Wood, D. D. J. Immun. 123, 2395–2399 (1979).

    CAS  PubMed  Google Scholar 

  17. Meikle, M. C., Gowen, M. & Reynolds, J. J. Calcified Tissue Int. 34, 359–364 (1982).

    Article  CAS  Google Scholar 

  18. Aarden, L. A. et al. J. Immun. 123, 2928–2929 (1979).

    CAS  Google Scholar 

  19. Mizel, S. B. Molec. Immun. 17, 571–577 (1980).

    Article  CAS  PubMed  Google Scholar 

  20. Dinarello, C. A., Bendtzen, K. & Wolff, S. M. Inflammation 6, 63–78 (1982).

    Article  CAS  PubMed  Google Scholar 

  21. Horton, J. E. et al. Science 177, 793–795 (1972).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Mundy, G. R., Raisz, L. G., Cooper, R. A., Schechter, G. P. & Salmon, S. E. New Engl. J. Med. 291, 1041–1046 (1974).

    Article  CAS  PubMed  Google Scholar 

  23. Luben, R. A. Biochem. biophys. Res. Commun. 84, 15–22 (1978).

    Article  CAS  PubMed  Google Scholar 

  24. Mundy, G. R., Luben, R. A., Raisz, L. G., Oppenheim, J. J. & Buell, D. N. New Engl. J. Med. 290, 867–871 (1974).

    Article  CAS  PubMed  Google Scholar 

  25. Yoneda, T. & Mundy, G. R. J. exp. Med. 150, 338–350 (1979).

    Article  CAS  PubMed  Google Scholar 

  26. Bockman, R. S. & Repo, M. J. exp. Med. 154, 529–539 (1981).

    Article  CAS  PubMed  Google Scholar 

  27. McGuire, M. K. B. et al. Int. J. Immunopharmac. 4, 91–102 (1982).

    Article  CAS  Google Scholar 

  28. Wood, D. D., Ihrie, E. J., Dinarello, C. A. & Cohen, P. L. Arthr. Rheum. 26, 975–983 (1983).

    Article  CAS  Google Scholar 

  29. Reynolds, J. J. in Organ Culture in Biomedical Research (eds Balls, M. & Monnickendam, M.) 355–366 (Cambridge University Press, 1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK

    Maxine Gowen, Mary K. B. McGuire & R. Graham G. Russell

  2. Department of Immunology, Merck Sharp and Dohme Research Laboratories, PO Box 2000, Rahway, New Jersey, 07065, USA

    David D. Wood & Earl J. Ihrie

Authors
  1. Maxine Gowen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David D. Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Earl J. Ihrie
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mary K. B. McGuire
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Graham G. Russell
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gowen, M., Wood, D., Ihrie, E. et al. An interleukin 1 like factor stimulates bone resorption in vitro. Nature 306, 378–380 (1983). https://doi.org/10.1038/306378a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/306378a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing