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Article
Nature 304, 507-513 (11 August 1983) | doi:10.1038/304507a0; Accepted 7 July 1983
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
Daniel J. Capon, Peter H. Seeburg, John P. McGrath, Joel S. Hayflick, Ursula Edman, Arthur D. Levinson & David V. Goeddel
- Department of Molecular Biology, Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080, USA
Abstract
Kirsten (Ki)-ras cDNA clones were prepared from human lung and colon carcinoma cell lines expressing an activated c-Ki-ras2 gene. DNA sequence analysis and transfection studies indicate that different point mutations at the same codon can activate the gene; that most human c-Ki-ras2 mRNA uses sequences from a fourth coding exon distinct from that of its viral counterpart; and that at least one cell line is functionally homozygous for the activated gene.
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