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Article
Nature 304, 412 - 417 (04 August 1983); doi:10.1038/304412a0

Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster

Martin Kreitman

Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts 02138, USA

The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious.

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