Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Saturday 23 September 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Article
Nature 298, 240 - 244 (15 July 1982); doi:10.1038/298240a0

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

Susan G. Amara*, Vivian Jonas*, Michael G. Rosenfeld*, Estelita S. Ong & Ronald M. Evans

*Division of Endocrinology, School of Medicine University of California, San Diego La Jolla, California 92093, USA
Tumor Virology Laboratory, The Salk Institute, San Diego, California 92138, USA

Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.

------------------

References

1. Blundell, T. L. & Humbel, R. E. Nature 287, 781−787 (1980). | PubMed | ISI | ChemPort |
2. Roberts, J. L., Phillips, M., Rosa, P. A., Herbert, E. Biochemistry 17, 3609−3618 (1978). | PubMed | ISI | ChemPort |
3. Eipper, B. A. & Mains, R. E. J. biol. Chem. 253, 5732−5744 (1978). | PubMed | ISI | ChemPort |
4. Nakanishi, S. et al. Nature 278, 423−427 (1979). | PubMed | ISI | ChemPort |
5. Ziff, E. B. Nature 287, 491−499 (1980). | PubMed | ISI | ChemPort |
6. Darnell, J. E. Prog. Nucleic Acid Res. molec Biol. 22, 327−353 (1978).
7. Rosenfeld, M. G., Amara, S. G., Roos, B. A., Ong, E. S. & Evans, R. M. Nature 290, 63−65 (1980). | ISI |
8. Rosenfeld, M. G. et al. Proc. natn. Acad. Sci. U.S.A. 79, 1717−1721 (1982). | ChemPort |
9. Amara, S. G., David, D. N., Rosenfeld, M. G., Roos, B. A. & Evans, R. M. Proc. natn. Acad. Sci. U.S.A. 77, 4444−4448 (1980). | ChemPort |
10. Amara, S. G. et al. J. biol. Chem. 257, 2129−2132 (1982). | PubMed | ISI | ChemPort |
11. Birnbaum, R. S., O'Neal, J. A., Muszynski, M., Aron, D. C. & Roos, B. A. J. biol. Chem. 257, 241−244 (1982). | PubMed | ISI | ChemPort |
12. Breathnach, F., Benoist, C., O'Hare, K., Gannon, F. & Chambon, P. Proc. natn. Acad. Sci. U.S.A. 75, 4853−4857 (1978).
13. Alt, F. W. et al. Cell 20, 293−301 (1980). | Article | PubMed | ISI | ChemPort |
14. Early, P. et al. Cell 20, 313−319 (1980). | Article | PubMed | ISI | ChemPort |
15. Maki, R. et al. Cell 24, 353−365 (1981). | Article | PubMed | ISI | ChemPort |
16. Kreil, G., Suchanek, G. & Kindas-Mugge, I. Fedn Proc. 36, 2081−2086 (1977). | ChemPort |
17. Chow, L. T., Gelinas, R. E., Broker, T. R. & Roberts, R. J. Cell 12, 1−8 (1977). | Article | PubMed | ISI | ChemPort |
18. Klessig, D. F. Cell 12, 9−21 (1977). | Article | PubMed | ISI | ChemPort |
19. Sambrook, J. Nature 268, 101−104 (1977). | PubMed | ISI | ChemPort |
20. Jeffreys, A. J. & Flavell, R. A. Cell 12, 1097−1108 (1977). | Article | PubMed | ISI | ChemPort |
21. Tilghman, S. M. et al. Proc. natn. Acad. Sci. U.S.A. 75, 725−729 (1978). | ChemPort |
22. Nevins, J. R. Cell 28, 1−2 (1982). | Article | PubMed | ISI | ChemPort |
23. Tosi, M., Young, R. A., Hagenbuchle, O. & Schibler, U. Nucleic Acids Res. 9, 2313−2323 (1981). | PubMed | ISI | ChemPort |
24. Setzer, D. R., McGrogan, M., Nunberg, J. H. & Schimke, R. T. Cell 22, 361−370 (1980). | Article | PubMed | ISI | ChemPort |
25. Young, R. A., Hagenbuchle, O. & Schibler, U. Cell 23, 451−458 (1981). | Article | PubMed | ISI | ChemPort |
26. Jacobs, J. W. et al. Science 213, 457−459 (1981). | PubMed | ISI | ChemPort |
27. Southern, E. M. J. molec. Biol. 98, 503−517 (1975). | PubMed | ISI | ChemPort |
28. Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560−564 (1977). | ChemPort |
29. Smith, H. O. & Birnstiel, M. L. Nucleic Acids Res. 3, 2387−2398 (1976). | PubMed | ISI | ChemPort |
30. Messing, J., Crea, R. & Seeburg, P. M. Nucleic Acids Res. 9, 309−321 (1981). | PubMed | ISI | ChemPort |
31. Sanger, F., Nicklen, S. & Coulsen, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463−5467 (1977). | ChemPort |
32. Fuhrman, S. A., Deininger, P. L., Laporte, P., Friedmann, T. & Geiduschek, E. P. Nucleic Acids Res. 9, 6439−6456 (1981). | PubMed | ISI | ChemPort |
33. Potter, E., Nicolaisen, A. K., Ong, E. S., Evans, R. M. & Rosenfeld, M. G. Proc. natn. Acad. Sci. U.S.A. 78, 6662−6666 (1981). | ChemPort |
34. Wahl, G. M., Stern, M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 76, 3683−3687 (1979). | ChemPort |



© 1982 Nature Publishing Group
Privacy Policy