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A possible case of hypervitaminosis A in Homo erectus

Nature volume 296, pages 248–250 (1982)Cite this article

Abstract

Following an initial discovery by Bw. K. Kimeu in 1973, sieving operations have recovered the most complete Homo erectus skeleton so far known (Fig. 1) from the Upper Member of the Koobi Fora Formation in Area 103, Koobi Fora, East Lake Turkana in Kenya1,2. The partial skeleton shows pathological changes consistent with chronic hypervitaminosis A. We attribute this disorder to the high dietary intake of animal liver, most probably that of carnivores, during a period when the dietary habits of Homo erectus were changing.

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References

  1. Leakey, M. G. & Leakey, R. E. Koobi Fora Research Project Vol. 1 (Clarendon, Oxford, 1978).

    Google Scholar 

  2. Leakey, R. E. F. Nature 248, 653–656 (1973).

    Article  ADS  Google Scholar 

  3. Fitch, F. J. & Miller, J. A. in Earliest Man and Environments in the Lake Rudolf Basin (eds Coppens, Y., Howell, F. C., Isaac, G. & Leakey, R. E. F.) 123–147 (University of Chicago, 1976).

    Google Scholar 

  4. MacDougall, I. in The Earth: its Structure, Origins and Evolution (ed. McElhinny, M. W.) 543–561 (Academic, London, 1979).

    Google Scholar 

  5. Leakey, R. E. F. Nature 261, 574–576 (1976).

    Article  ADS  CAS  Google Scholar 

  6. Day, M. H. Nature 232, 363–381 (1971).

    Article  ADS  Google Scholar 

  7. Gerber, A., Raab, A. P. & Sobel, A. E. Am. J. Med. 16, 729–745 (1954).

    Article  CAS  Google Scholar 

  8. Shearman, D. J. C. Br. med. J. 1, 283–285 (1978).

    Article  CAS  Google Scholar 

  9. Rodahl, K. & Moore, T. Biochem. J. 37, 166–168 (1943).

    Article  CAS  Google Scholar 

  10. Furman, K. I. Am. J. clin. Nutr. 26, 575–577 (1973).

    Article  CAS  Google Scholar 

  11. Bergen, S. S. & Roels, O. A. Am. J. clin. Nutr. 16, 265–269 (1965).

    Article  Google Scholar 

  12. Mahoney, C. P., Margolis, M. T., Krauss, T. A. & Labbe, R. F. Pediatrics 65, 893–896 (1980).

    CAS  PubMed  Google Scholar 

  13. Pease, C. N. J. Am. med. Ass. 182, 980–985 (1962).

    Article  CAS  Google Scholar 

  14. Ruby, L. K. & Mital, M. A. J. Bone Jt Surg. 56, 1283–1287 (1974).

    Article  CAS  Google Scholar 

  15. Bifulco, E. Am. J. clin. Nutr. 16, 265–269 (1965).

    Article  Google Scholar 

  16. DiBenedetto, R. J. J. Am. med. Ass. 201, 700–702 (1967).

    Article  CAS  Google Scholar 

  17. Frame, B., Jackson, C. E., Reynolds, W. A. & Umphrey, J. E. Ann. intern. Med. 80, 44–48 (1974).

    Article  CAS  Google Scholar 

  18. Hofmann, K. J., Milne, F. J. & Schmidt, C. S. Afr. med. J. 54, 579–580 (1978).

    Google Scholar 

  19. Jowsey, J. & Riggs, B. L. J. clin. Endocr. 28, 1833–1835 (1968).

    Article  CAS  Google Scholar 

  20. Katz, C. M. & Tzagournis, M. Metabolism 21, 1171–1176 (1972).

    Article  CAS  Google Scholar 

  21. Stimson, W. H. New Engl. J. Med. 265, 369–373 (1961).

    Article  Google Scholar 

  22. Sulzberger, M. B. & Lazer, M. P. J. Am. med. Ass. 146, 788–793 (1951).

    Article  CAS  Google Scholar 

  23. Haworth, J. C. et al. Can. med. Ass. J. 104, 521–522 (1971).

    Google Scholar 

  24. Shaywitz, G. A., Siegel, N. J. & Pearson, H. A. J. Am. med. Ass. 238, 1749–1750 (1977).

    Article  CAS  Google Scholar 

  25. Clark, I. & Smith, M. R. J. Biochem. Chem. 239, 1266–1271 (1964).

    CAS  Google Scholar 

  26. Wolke, R. E., Eaton, H. D., Nielson, S. W. & Helmboldt, C. F. Am. J. Path. 98, 677–685 (1969).

    Article  Google Scholar 

  27. Bélanger, L. F. & Clark, I. Anat. Rec. 158, 443–452 (1967).

    Article  Google Scholar 

  28. Lichtenstein, L. Diseases of Bones and Joints (Mosby, St Louis, 1970).

    Google Scholar 

  29. Teitelbaum, S. L. in Pathology 7th edn (eds Anderson, W. A. D. & Kissane,J. M. )1905–1977 (Mosby, St Louis, 1977).

    Google Scholar 

  30. Edeiken, J. & Hodes, P. J. Roentgen Diagnosis of Diseases of Bone (Williams & Wilkins, Baltimore, 1973).

    Google Scholar 

  31. Aegerter, E. & Kirkpatrick, J. A. Orthopedic Diseases 3rd edn (Saunders, Philadelphia, 1968).

    Google Scholar 

  32. Cockshott, P. & MacGregor, M. Q. Jl Med. 27, 369–387 (1958).

    CAS  Google Scholar 

  33. Davidson, J. C. & Palmer, P. E. S. J. Bone Jt Surg. 458, 687–693 (1963).

    Article  Google Scholar 

  34. Eaton, R. L. Carnivore 2, 9–16 (1979).

    Google Scholar 

  35. Moore, T. Vitamin A (Elsevier, Amsterdam, 1957).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cell Biology and Anatomy, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, 21205, USA

    A. Walker

  2. Department of Pathology and Laboratory Medicine, Hahnemann Medical College and Hospital of Philadelphia, Philadelphia, Pennsylvania, 19102, USA

    M. R. Zimmerman

  3. National Museums of Kenya, Box 40658, Nairobi, Kenya

    R. E. F. Leakey

Authors
  1. A. Walker
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  2. M. R. Zimmerman
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  3. R. E. F. Leakey
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Walker, A., Zimmerman, M. & Leakey, R. A possible case of hypervitaminosis A in Homo erectus. Nature 296, 248–250 (1982). https://doi.org/10.1038/296248a0

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