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Article
Nature 289, 366-373 (29 January 1981) | doi:10.1038/289366a0; Accepted 16 November 1980
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution
I. A. Wilson, J. J. Skehel* & D. C. Wiley
- Gibbs Laboratory, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138
- *National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
Abstract
The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of 
-helices extends 76 Å from the membrane and a globular region of antiparallel 
-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 Å distally and folding back to enter the membrane.
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