Nature 289, 373 - 378 (29 January 1981); doi:10.1038/289373a0

Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

D. C. Wiley^*, I. A. Wilson^* & J. J. Skehel^†

^*Gibbs Laboratory, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138
^†National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

Four 'antigenic sites' on the three-dimensional structure of the influenza haemagglutinin are identified. At least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.

References

1.	Wilson, I. A., Skehel, J. J. & Wiley, D. C. Nature 289, 366−373 (1981). | Article | PubMed | ISI | ChemPort |
2.	Webster, R. G. & Laver, W. G. in The Influenza Viruses and Influenza (ed. Kilbourne, E. D.) 269−314 (Academic, New York, 1975). | ChemPort |
3.	Porter, A. G. et al. Nature 282, 471−477 (1979). | PubMed | ISI | ChemPort |
4.	Ward, C. W. & Dopheide, T. A. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 27−38 (Elsevier, Amsterdam, 1980). | ChemPort |
5.	Dopheide, T. A. & Ward, C. W. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 21−26 (Elsevier, Amsterdam, 1980). | ChemPort |
6.	Sleigh, M. J., Both, G. W., Brownlee, G. G., Bender, V. J. & Moss, B. A. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 69−78 (Elsevier, Amsterdam, 1980). | ChemPort |
7.	Gething, M. J., Bye, J., Skehel, J. & Waterfield, M. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 1−10 (Elsevier, Amsterdam, 1980). | ChemPort |
8.	Min Jou, W. et al. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 63−68 (Elsevier, Amsterdam, 1980).
10.	Verhoeyen, M. et al. Nature 286, 771−776 (1980). | PubMed | ISI | ChemPort |
11.	Ward, C. W. & Dopheide, T. A. Biochem. J. (submitted).
12.	Threlfall, G., Barber, C., Carey, N. & Emtage, S. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 51−61 (Elsevier, Amsterdam, 1980). | ChemPort |
13.	Min Jou, W. et al. Cell 19, 683−696 (1980). | PubMed |
14.	Gething, M.-J., Bye, J., Skehel, J. & Waterfield, M. Nature 287, 301−306 (1980). | PubMed | ISI | ChemPort |
15.	Both, G. W., Sleigh, M. J., Bender, V. J. & Moss, B. A. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 81−89 (Elsevier, Amsterdam, 1980). | ChemPort |
16.	Moss, B. A., Underwood, P. A., Bender, V. J. & Whittaker, R. G. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 329−338 (Elsevier, Amsterdam, 1980). | ChemPort |
17.	Smith, W., Andrewes, G. H. & Laidlaw, P. P. Lancet ii, 66−68 (1933). | Article |
18.	World Health Organization (1971) Bull. Wld. Hlth. Org. 45, 119−124 (1971).
19.	Burnett, F. M. Principles of Animal Virology, 382 (1955).
20.	Pereira, M. S. Br. Med. Bull. 35, 9−14 (1979). | PubMed | ISI | ChemPort |
21.	Stewart-Harris, C. Br. Med. Bull. 35, 3−8 (1979). | PubMed | ChemPort |
22.	Laver, W. G. et al. in Structure and Variation in Influenza Virus (eds Laver, W. G. & Air, G. M.) 295−306 (Elsevier, Amsterdam, 1980). | ChemPort |
23.	Fazekes de St. Groth, S. Topics Infect. Dis. 3, 25−48 (1978).
24.	Laver, W. G. et al. Virology 98, 226−237 (1979). | Article | PubMed | ISI | ChemPort |
25.	Webster, R. G. & Laver, W. G. Virology 104, 139−148 (1980). | Article | PubMed | ISI | ChemPort |
26.	Atassi, M. Z. & Smith, J. A. Immunochemistry 15, 609−610 (1978). | Article | PubMed | ISI | ChemPort |
27.	Atassi, M. Z. Immunochemistry 15, 909−936 (1978). | Article | PubMed | ISI | ChemPort |
28.	Atassi, M. Z. Immunochemistry 12, 423−438 (1975). | Article | PubMed | ISI | ChemPort |
29.	Public Health Laboratory Service Standing Advisory Committee on Influenza J. Hyg., Camb. 78, 223−233 (1977).
30.	Assad, F. A., Cockburn, W. C. & Sundaresan, T. K. Bull. Wld Hlth Org. 49, 219−233 (1973).