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Article
Nature 289, 366 - 373 (29 January 1981); doi:10.1038/289366a0

Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution

I. A. Wilson, J. J. Skehel* & D. C. Wiley

Gibbs Laboratory, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138
*National Institute for Medical Research, Mill Hill, London NW7 1AA, UK

The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of α-helices extends 76 Å from the membrane and a globular region of antiparallel β-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 Å distally and folding back to enter the membrane.

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