Nature 287, 22 - 25 (04 September 1980); doi:10.1038/287022a0

Enkephalin blocks inhibitory pathways in the vertebrate CNS

R. A. Nicoll, B. E. Alger & C. E. Jahr

Departments of Pharmacology and Physiology, University of California, San Francisco, California 94143

Enkephalin markedly attenuates a variety of GABAergic inhibitory pathways in the CNS, but does not affect the action of GABA. The action of enkephalin is reversed by the specific opiate antagonist, naloxone. Thus, inhibitory interneurones may be primary targets for opioid peptide-containing pathways and disinhibition may be of general importance for opioid peptide action in the CNS.

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