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Distinctive sequence of human mitochondrial ribosomal RNA genes

Abstract

The nucleotide sequence spanning the ribosomal RNA (rRNA) genes of cloned human mitochondrial DNA reveals an extremely compact genome organization wherein the putative tRNA genes are probably ‘butt-jointed’ around the two rRNA genes. The sequences of the rRNA genes are significantly homologous in some regions to eukaryotic and prokaryotic sequences, but distinctive ; the tRNA genes also have unusual nucleotide sequences. It seems that human mitochondria did not originate from recognizable relatives of present day organisms.

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References

  1. Attardi, G. & Ching, E. Meth. Enzym. 56, 66–79 (1979).

    CAS  PubMed  Google Scholar 

  2. Attardi, G. et al. in Proc. ICN–UCLA Symp. on Extrachromosomal DNA (in the press).

  3. Vesco, C. & Penman, S. Proc. natn. Acad. Sci. U.S.A. 62, 218–225 (1969).

    ADS  CAS  Google Scholar 

  4. Attardi, B. & Attardi, G. J. molec. Biol. 55, 231–249 (1971).

    CAS  PubMed  Google Scholar 

  5. Attardi, G. & Ojala, D. Nature new Biol. 229, 133–136 (1971).

    CAS  PubMed  Google Scholar 

  6. Brega, A. & Vesco, C. Nature new Biol. 229, 136–139 (1971).

    ADS  CAS  PubMed  Google Scholar 

  7. Aloni, Y. & Attardi, G. J. molec. Biol. 55, 271–276 (1971).

    CAS  PubMed  Google Scholar 

  8. Robberson, D., Aloni, Y., Attardi, G. & Davidson, N. J. molec. Biol. 64, 313–317 (1972).

    CAS  PubMed  Google Scholar 

  9. Angerer, K., Davidson, N., Murphy, W., Lynch, D. & Attardi, G. Cell 9, 81–90 (1976).

    CAS  PubMed  Google Scholar 

  10. Ojala, D. & Attardi, G. Plasmid 1, 78–105 (1977).

    CAS  PubMed  Google Scholar 

  11. Schatz, G. & Mason, T. L. A. Rev. Biochem. 43, 51–87 (1974).

    CAS  Google Scholar 

  12. Buse, G. & Steffens, G. J. Hoppe-Seyler's Z. physiol. Chem. 359, 1005–1009 (1978).

    CAS  Google Scholar 

  13. Cunningham, R. S., Bonen, L., Doolittle, W. F. & Gray, M. W. FEBS Lett. 69, 116–122 (1976).

    CAS  PubMed  Google Scholar 

  14. Schwarz, Z. & Kössel, H. Nature 283, 739–742 (1980).

    ADS  CAS  Google Scholar 

  15. Drouin, J. J. molec. Biol. (in the press).

  16. Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    ADS  CAS  Google Scholar 

  17. Smith, A. J. H. Nucleic Acids Res. 6, 831–848 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Zain, B. S. & Roberts, R. J. J. molec. Biol. 131, 341–352 (1979).

    CAS  PubMed  Google Scholar 

  19. Brown, N. L. FEBS Lett. 93, 10–15 (1978).

    CAS  PubMed  Google Scholar 

  20. Eshaghpour, H. & Crothers, D. M. Nucleic Acids Res. 5, 13–21 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Messing, J., Gronenborn, B., Müller-Hill, B. & Hofschneider, P. H. Proc. natn. Acad. Sci. U.S.A. 74, 3642–3646 (1977).

    ADS  CAS  Google Scholar 

  22. Schreier, P. H. & Cortese, R. J. molec. Biol. 129, 169–172 (1979).

    CAS  PubMed  Google Scholar 

  23. Rothstein, R.J., Lall, L.F., Bahl, C.P., Narang, S.A. & Wu, R. Meth. Enzym. (in the press).

  24. Clark, B. F. C. & Klug, A. in Proc. 10th FEBS Meet. 183–206 (1975).

    Google Scholar 

  25. Gaun, D. H., Grüter, F. & Springl, M. Nucleic Acids Res. 6 r, r1–r19 (1979).

    Google Scholar 

  26. Goodman, H. M., Olson, M. V. & Hall, B. D. Proc. natn. Acad. Sci. U.S.A. 74, 5453–5457 (1977).

    ADS  CAS  Google Scholar 

  27. Valenzuela, P., Venegas, A., Weinberg, F., Bishop, R. & Rutter, W.J. Proc. natn. Acad. Sci. U.S.A. 75, 190–194 (1978).

    ADS  CAS  Google Scholar 

  28. Knapp, G., Beckmann, J.G., Johnson, P.F., Furhonan, S.A. & Abelson, J. Cell 14, 221–236 (1978).

    CAS  PubMed  Google Scholar 

  29. Amalric, F., Merkel, C., Gelfand, R. & Attardi, G. J. molec. Biol. 118, 1–25 (1978).

    CAS  PubMed  Google Scholar 

  30. Young, R. A. & Steitz, J. A. Proc. natn. Acad. Sci. U.S.A. 75, 3593–3597 (1978).

    ADS  CAS  Google Scholar 

  31. Dahlberg, A. E. et al. Proc. natn. Acad. Sci. U.S.A. 75, 3598–3602 (1978).

    ADS  CAS  Google Scholar 

  32. Boseley, P., Moss, T., Mächler, M., Portmann, R. & Birnstiel, M. Cell 17, 19–31 (1979).

    CAS  PubMed  Google Scholar 

  33. Frankel, G., Cockburn, A. F., Kindle, K. L. & Firtel, R. M. J. molec. Biol. 109, 539–558 (1977).

    CAS  PubMed  Google Scholar 

  34. Skryabin, K. G., Karyev, A. S., Rubtsov, P. M. & Bayev, A. A. Dokl. (Proc.) Acad. Sci. U.S.S.R. 247, 761–765 (1979).

    CAS  Google Scholar 

  35. Garber, R. L. & Altman, S. Cell 17, 389–397 (1979).

    CAS  PubMed  Google Scholar 

  36. Stark, B. C., Kole, R., Bowman, E. J. & Altman, S. Proc. natn. Acad. Sci. U.S.A. 75, 3717–3721 (1978).

    ADS  CAS  Google Scholar 

  37. Brown, W. M. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 71, 4617–4621 (1974).

    ADS  CAS  Google Scholar 

  38. Ojala, D. & Attardi, G. J. molec. Biol. 122, 301–319 (1978).

    CAS  PubMed  Google Scholar 

  39. Crews, S., Ojala, D., Posakony, J., Nishiguchi, J. & Attardi, G. Nature 277, 192–198 (1979).

    ADS  CAS  PubMed  Google Scholar 

  40. Rosenberg, M. & Court, D. A. Rev. Genet. (in the press).

  41. Young, R. A. & Steitz, J. A. Cell 17, 225–234 (1979).

    CAS  PubMed  Google Scholar 

  42. Gilbert, S. F., de Boer, H. A. & Nomura, M. Cell 17, 211–224 (1979).

    CAS  PubMed  Google Scholar 

  43. Mueller, K., Oebbecke, C. & Förster, G. Cell 10, 121–130 (1977).

    CAS  PubMed  Google Scholar 

  44. Moss, T. & Birnstiel, M. Nucleic Acids Res. 6, 3733–3743 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Barrell, B. G., Bankier, A. T. & Drouin, J. Nature 282, 189–194 (1979).

    ADS  CAS  PubMed  Google Scholar 

  46. Heckman, J. E. et al. Cell 13, 83–95 (1978).

    CAS  PubMed  Google Scholar 

  47. Jack, A., Ladner, J. E. & Klug, A. J. molec. Biol. 108, 619–649 (1976).

    CAS  PubMed  Google Scholar 

  48. Macino, G. & Tzagoloff, A. Proc. natn. Acad. Sci. U.S.A. 76, 131–135 (1979).

    ADS  CAS  Google Scholar 

  49. Hensgens, L. A. M., Grivell, L. A., Borst, P. & Bos, T.L. Proc. natn. Acad. Sci. USA. 76, 1663–1667 (1979).

    ADS  CAS  Google Scholar 

  50. Macino, G., Couzzi, G., Nobrega, F.G., Li, M. & Tzagoloff, A. Proc. natn. Acad. Sci. U.S.A. 76, 3784–3785 (1979).

    ADS  CAS  Google Scholar 

  51. Larue, B., Cedergren, R. J., Sankoff, D. & Grosjean, H. J. molec. Evol. 14, 287–300 (1979).

    ADS  CAS  PubMed  Google Scholar 

  52. Martin, R. P. et al. Nucleic Acids Res. 5, 4579–4592 (1978).

    ADS  CAS  PubMed  PubMed Central  Google Scholar 

  53. Lynch, D. C. & Attardi, G. J. molec. Biol. 102, 125–141 (1976).

    CAS  PubMed  Google Scholar 

  54. Brosius, J., Dull, T. J. & Noller, H. F. Proc. natn. Acad. Sci. U.S.A. (in the press).

  55. Herr, W. & Noller, H. F. J. molec. Biol. 130, 421–432 (1979).

    CAS  PubMed  Google Scholar 

  56. Ehresmann, C., Stiegler, P., Carbon, P. & Ebel, J.-P. FEBS Lett. 84, 337–341 (1977).

    CAS  PubMed  Google Scholar 

  57. Brosius, J., Palmer, M. L., Kennedy, P. J. & Noller, H. F. Proc. natn. Acad. Sci. U.S.A. 75, 4801–4805 (1978).

    ADS  CAS  Google Scholar 

  58. Shine, J. & Dalgarno, L. Proc. natn. Acad. Sci. U.S.A. 71, 1342–1346 (1974).

    ADS  CAS  Google Scholar 

  59. Steitz, J. A. & Jakes, K. Proc. natn. Acad. Sci. U.S.A. 72, 4734–4738 (1975).

    ADS  CAS  Google Scholar 

  60. Shine, J. & Dalgarno, L. Nature 254, 34–38 (1975).

    ADS  CAS  PubMed  Google Scholar 

  61. Sprague, K. U., Steitz, J. A., Grenley, R. M. & Stocking, C. E. Nature 267, 462–465 (1977).

    ADS  CAS  PubMed  Google Scholar 

  62. Hagenbüchle, O., Santer, M., Steitz, J. A. & Mans, R. J. Cell 13, 551–563 (1978).

    PubMed  Google Scholar 

  63. Hunter, A. R., Jackson, R. J. & Hunt, T. Eur. J. Biochem. 75, 159–170 (1977).

    CAS  PubMed  Google Scholar 

  64. Kozak, M. Cell 15, 1109–1123 (1978).

    CAS  PubMed  Google Scholar 

  65. Filipowicz, W. & Haenni, A.-L. Proc. natn. Acad. Sci. U.S.A. 76, 3111–3115 (1979).

    ADS  CAS  Google Scholar 

  66. Ahlquist, P., Dasgupta, R., Shih, D.S., Zimmern, D. & Kaesberg, P. Nature 281, 277–282 (1979).

    ADS  CAS  PubMed  Google Scholar 

  67. Paterson, B. M. & Rosenberg, M. Nature 279, 692–696 (1979).

    ADS  CAS  PubMed  Google Scholar 

  68. Rosenberg, M. & Paterson, B. M. Nature 279, 696–701 (1979).

    ADS  CAS  PubMed  Google Scholar 

  69. Walz, A., Pirrotta, V. & Ineichen, K. Nature 262, 665–669 (1976).

    ADS  CAS  PubMed  Google Scholar 

  70. Moorman, A.F.M., Verkley, F.N., Asselbergs, F.A.M. & Grivell, L. A. in Mitochondria 1977: Genetics and Biogenesis of Mitochondria (eds Bandlow, W. et al.) 385–400 (De Gruyter, Berlin, 1977).

    Google Scholar 

  71. Chang, A. C. Y., Lansman, R. A., Clayton, D. A. & Cohen, S. N. Cell 6, 231–244 (1975).

    CAS  PubMed  Google Scholar 

  72. Woese, C. R. Nature 254, 83–86 (1975).

    ADS  CAS  PubMed  Google Scholar 

  73. Herr, W., Chapman, N. M. & Noller, H. F. J. molec. Biol. 130, 433–449 (1979).

    CAS  PubMed  Google Scholar 

  74. Henderson, C. E., Perham, R. N. & Finch, J. T. Cell 17, 85–93 (1979).

    CAS  PubMed  Google Scholar 

  75. Whatley, J. M., John, P. & Whatley, F. R. Proc. R. Soc. B204, 165–187 (1979).

    ADS  CAS  Google Scholar 

  76. Schwartz, R. M. & Dayhoff, M. O. Science 199, 395–403 (1978).

    ADS  CAS  PubMed  Google Scholar 

  77. Staden, R. Nucleic Acids Res. 4, 4037–4051 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  78. Zablen, L. B. & Woese, C. R. J. molec. Evol. 5, 25–34 (1975).

    ADS  CAS  PubMed  Google Scholar 

  79. Fox, G. E., Pechman, K. R. & Woese, C. R. Int. J. systemic Bact. 27, 44–57 (1977).

    CAS  Google Scholar 

  80. Magrum, L. J., Luehosen, K. R. & Woese, C. R. J. molec. Evol. 11, 1–8 (1978).

    ADS  CAS  PubMed  Google Scholar 

  81. Woese, C. R., Magrum, L. J. & Fox, G. E. J. molec. Evol. 11, 245–252 (1978).

    ADS  CAS  PubMed  Google Scholar 

  82. Bonen, L., Cunningham, R. S., Gray, M. W. & Doolittle, W. F. Nucleic Acids Res. 4, 663–671 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Klootwijk, J., Klein, I. & Grivell, L. A. J. molec. Biol. 97, 337–350 (1975).

    CAS  PubMed  Google Scholar 

  84. Dubin, D. T., Taylor, R. H. & Daveport, L. W. Nucleic Acids Res. 5, 4385–4397 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  85. Borst, P. & Grivell, L. A. Cell 15, 705–725 (1978).

    CAS  PubMed  Google Scholar 

  86. Sanger, F. & Coulson, A. R. FEBS Lett. 87, 107–110 (1978).

    CAS  PubMed  Google Scholar 

  87. Crews, F. & Attardi, G. Cell 19, 775–784 (1980).

    CAS  PubMed  Google Scholar 

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Eperon, I., Anderson, S. & Nierlich, D. Distinctive sequence of human mitochondrial ribosomal RNA genes. Nature 286, 460–467 (1980). https://doi.org/10.1038/286460a0

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