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Nature 279, 805 - 806 (28 June 1979); doi:10.1038/279805a0

Neuronal localisation of immunoreactive enkephalin and β-endorphin in the earthworm


Departments of Histology and Pharmacology, University of Lund, Lund, Sweden and Department of Nuclear Medicine, University of Lund at Malmö General Hospital, Malmö, Sweden

SINCE the report by Simantov et al. 1 invertebrates have been thought to lack endogenous opiates and opiate receptors. As we have previously observed peptidergic neurones containing immunoreactive pancreatic polypeptide or vasoactive intestinal peptide in the earthworm2, we decided to search for, and report here our finding of, nerves storing immunoreactive enkephalin or β-endorphin in this species.



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