Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication

Abstract

A fragment of HeLa cell mitochondrial DNA containing the origin of replication has been sequenced. The precise position of the origin in this sequence has been identified by determining the nucleotide order in the 5′-end proximal portion of the heavy strand initiation fragment (7S DNA), and by aligning the two sequences.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Robberson, D. L., Kasamatsu, H. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 69, 737–741 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Robberson, D. L. & Clayton, D. A. Proc. natn. Acad. Sci. U.S.A. 69, 3810–3814 (1972).

    Article  ADS  CAS  Google Scholar 

  3. Kasamatsu, H. & Vinograd, J. A. Rev. Biochem. 43, 695–719 (1974).

    Article  CAS  Google Scholar 

  4. Wolstenholme, D. R., Koike, K. & Cochran-Fouts, P. J. Cell Biol. 56, 230–245 (1973).

    Article  CAS  Google Scholar 

  5. Matsumoto, L., Kasamatsu, H., Piko, L. & Vinograd, J. J. Cell Biol. 63, 146–159 (1974).

    Article  CAS  Google Scholar 

  6. Rubenstein, J. L. R., Brutlag, D. & Clayton, D. A. Cell 12, 471–482 (1977).

    Article  CAS  Google Scholar 

  7. Kasamatsu, H., Robberson, D. L. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 68, 2252–2257 (1971).

    Article  ADS  CAS  Google Scholar 

  8. Gillum, A. M. & Clayton, D. A. Proc. natn. Acad. Sci. U.S.A. 75, 677–681 (1978).

    Article  ADS  CAS  Google Scholar 

  9. Brown, W. M., Shine, J. & Goodman, H. M. Proc. natn. Acad. Sci. U.S.A. 75, 735–739 (1978).

    Article  ADS  CAS  Google Scholar 

  10. Bogenhagen, D. & Clayton, D. A. J. molec. Biol. 119, 49–68 (1978).

    Article  CAS  Google Scholar 

  11. Albring, M., Griffith, J. & Attardi, G. Proc. natn. Acad. Sci. U.S.A. 74, 1348–1352 (1977).

    Article  ADS  CAS  Google Scholar 

  12. Ojala, D. & Attardi, G. Plasmid 1, 78–105 (1977).

    Article  CAS  Google Scholar 

  13. Ojala, D. & Attardi, G. J. molec. Biol. 122, 301–319 (1978).

    Article  CAS  Google Scholar 

  14. Brown, W. M. & Vinograd, J. Proc. natn. Acad. Sci. U.S.A. 71, 4617–4621 (1974).

    Article  ADS  CAS  Google Scholar 

  15. Angerer, L., Davidson, N., Murphy, W., Lynch, D. & Attardi, G. Cell 9, 81–90 (1976).

    Article  CAS  Google Scholar 

  16. Maxam, A. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 74, 560–564 (1977).

    Article  ADS  CAS  Google Scholar 

  17. Van de Sande, J. H., Kleppe, K. & Khorana, H. G. Biochemistry 12, 5050–5055 (1973).

    Article  CAS  Google Scholar 

  18. Berkner, K. L. & Folk, W. R. J. biol. Chem. 252, 3176–3184 (1977).

    CAS  PubMed  Google Scholar 

  19. Efstratiadis, A., Kafatos, F. C. & Maniatis, T. Cell 10, 571–585 (1977).

    Article  CAS  Google Scholar 

  20. Simoncsits, A., Brownlee, G. G., Brown, R. S., Rubin, J. R. & Guilley, H. Nature 269, 833–836 (1977).

    Article  ADS  CAS  Google Scholar 

  21. Fujimoto, M., Kuninaka, A. & Yoshino, H. Agr. biol. Chem. 38, 1555–1561 (1974).

    Article  CAS  Google Scholar 

  22. Randerath, K. & Randerath, E. Analyt. Biochem. 13, 575–579 (1965).

    Article  CAS  Google Scholar 

  23. Miyamoto, C. & Denhardt, D. T. J. molec. Biol. 116, 681–707 (1977).

    Article  CAS  Google Scholar 

  24. Flory, J. P. thesis, Calif. Inst. Tech. (1976).

  25. Boezi, J. A. & Armstrong, R. L. Meth. Enzym. 12, A, 684–686 (1967).

    Article  Google Scholar 

  26. Bailey, J. M. & Davidson, N. Analyt. Biochem. 70, 75–85 (1977).

    Article  Google Scholar 

  27. Godson, G. N. & Roberts, R. J. Virology 73, 561–567 (1976).

    Article  CAS  Google Scholar 

  28. Attardi, G., Crews, S. T., Nishiguchi, J., Ojala, D. K. & Posakony, J. W. Cold Spring Harb. Symp. quant. Biol. 43 (in the press).

  29. Pribnow, D. Proc. natn. Acad. Sci. U.S.A. 72, 784–788 (1975).

    Article  ADS  CAS  Google Scholar 

  30. Tomizawa, J.-L., Ohmori, H. & Bird, R. E. Proc. natn. Acad. Sci. U.S.A. 74, 1865–1869 (1977).

    Article  ADS  CAS  Google Scholar 

  31. Langeveld, S. A. et al. Nature 271, 417–420 (1978).

    Article  ADS  CAS  Google Scholar 

  32. Geider, K., Beck, E. & Schaller, H. Proc. natn. Acad. Sci. U.S.A. 75, 645–649 (1978).

    Article  ADS  CAS  Google Scholar 

  33. Giddes, J. C., Barrell, B. G. & Godson, G. N. Proc. natn. Acad. Sci. U.S.A. 75, 1081–1085 (1978).

    Article  ADS  Google Scholar 

  34. Kallenbach, N. R. J. molec. Biol. 37, 445–466 (1968).

    Article  CAS  Google Scholar 

  35. Tinoco, I. Jr, et al. Nature new Biol. 246, 40–41 (1973).

    Article  CAS  Google Scholar 

  36. Borer, P. N., Dengler, B., Tinoco, L., Jr . & Uhlenbeck, D. C. J. molec. Biol. 86, 843–853 (1974).

    Article  CAS  Google Scholar 

  37. Gralla, J. & Crothers, D. M. J. molec. Biol 73, 497–511 (1973).

    Article  CAS  Google Scholar 

  38. Subramanian, K. N., Dhar, R. & Weissman, S. M. J. biol Chem. 252, 355–367 (1977).

    CAS  PubMed  Google Scholar 

  39. Tijan, R. Cell 13, 165–179 (1978).

    Article  Google Scholar 

  40. Dhar, R., Lai, C.-J. & Khoury, G. Cell 13, 345–358 (1978).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crews, S., Ojala, D., Posakony, J. et al. Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication. Nature 277, 192–198 (1979). https://doi.org/10.1038/277192a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/277192a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing