Nature 271, 325 - 329 (26 January 1978); doi:10.1038/271325a0

Can a myosin molecule bind to two actin filaments?

Gerald Offer & Arthur Elliott

Department of Biophysics, King's College, 26−29 Drury Lane, London WC2, UK

It is suggested that in striated muscles the two heads of one myosin molecule are able to interact with different actin filaments. This would provide a simple explanation for the appearance and arrangement of cross-bridges in insect flight muscle in rigor.

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