Abstract
THE C-Fragment of β-lipotropin (lipotropin 61-91), was first discovered as an intact peptide in the pituitary gland1,2 and it has recently been shown to be present in brain3. The peptide binds strongly to brain opiate receptors in vitro4,5 and has potent opiate-like actions on the guinea pig ileum and mouse vas deferens15. Reports from our laboratory described the potent analgesic properties of C-Fragment when injected into the cerebral ventricles of the cat4–6, and in subsequent studies its analgesic effects have been demonstrated in rodents7–9. The results reported here confirm the analgesic potency of C-Fragment administered intracerebrally in the rat, and show that chronic administration of the peptide leads to the development of tolerance to its analgesic actions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bradbury, A. F., Smyth, D. G., and Snell, C. R., in Peptides: Chemistry, Structure and Biology (edit. by Meienhofer, J.), 609–615 (Ann Arbor Sci. Inc., Ann Arbor, 1975).
Bradbury, A. F., Smyth, D. G., and Snell, C. R., in Peptide Hormones: Molecular and Cellular Aspects, CIBA Foundation Symposium No. 41 (edit. by Fitzsimmons, D. W.). 61–75 (Churchill, London, 1976).
Bradbury, A. F., Feldberg, W. S., Smyth, D. G., and Snell, C. R., in Opiates and Endogenous Opirid Peptides (edit. by Kosterktz, H. W.), 9–17 (Norht-Holland, Amsterdam, 1976).
Bradbury, A. F., Smyth, D. G., Snell, C. R., Birdsall, N. J. M., and Hulme, E. C., Nature 260, 793–795 (1976).
Lazarus, L. H., Ling, N., and Guillemin, R., Proc. natn. Acad. Sci. U.S.A., 73, 2156–2159 (1976).
Feldberg, W. S., and Smyth, D. G., J. Physiol., Lond., 260, 30P (1976).
Loh, H. H., Tseng, L-F., Wei, E., and Li, C. H., Proc. natn. Acad. Sci. U.S.A. 73, 2895–2898 (1976).
Graf, L., Szekely, J. F., Ronai, A. Z., Dunai-Kovacs, Z., and Bajazs, S., Nature 263, 240–241 (1976).
Bradbury, A. F., Smyth, D. G., Snell, C. R., Deakin, J. F. W., and Wendlandt, S., Biochem. Biophys Res. Commun. (in the press).
Gispen, W. H., Wiegant, V. M., Greven, H. M., and de Wied, D., Life Sci., 17, 645–652 (1975).
Eddy, N. B., and Leimbach, D., J. Pharmac. exp. Ther., 107, 385–393 (1953).
van Ree, J. M., and de Wied, D., in Opiates and Endogenous Opioid Peptides (edit. by Kosterlitz, H. W.), 443–445 (North Holland, Amsterdam, 1976).
Wei, E., in Opiates and Endogenous Opioid Peptides (edit. by Kosterlitz, H. W.), 303–310 (North Holland, Amsterdam, 1976).
Rosenfeld, J. P., and Kowatch, R., Brain Res., 88, 181–185 (1975).
Lord, J. A. H., Waterfield, A. A., Hughes, J., and Kosterlitz, H. W., in Opiates and Endogenous Opioid Peptides (edit. by Kosterlitz, H. W.), 275–280 (North Holland, Amseterdam, 1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
VAN REE, J., DE WIED, D., BRADBURY, A. et al. Induction of tolerance to the analgesic action of lipotropin C-Fragment. Nature 264, 792–794 (1976). https://doi.org/10.1038/264792a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/264792a0
This article is cited by
-
Genetics of alcoholism: Role of the endogenous opioid system
Metabolic Brain Disease (1994)
-
Effect of acute administration of Δ1-tetrahydrocannabinol on β-endorphin levels in plasma and brain tissue of the rat
Experientia (1987)
-
Plasma endorphin levels in pathological gambling
Journal of Gambling Behavior (1986)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
