Abstract
THE mitotic cell cycle is an orderly sequence of events, leading to cell division. In mammalian cell lines, a single event in the cycle exhibits first-order kinetics1, apparently dividing a cell's lifespan into a probabilistic state and a deterministic phase, termed A and B respectively. This rate-limiting event occurs during the G1 phase2,3, but its relation to the resting state and to the initiation of the cell cycle is unclear. In this paper we suggest that a probabilistic event exists in the mitotic cell cycle of yeast and that it can be identified with the initiation of a new cycle from the resting state.
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SHILO, B., SHILO, V. & SIMCHEN, G. Cell-cycle initiation in yeast follows first-order kinetics. Nature 264, 767–770 (1976). https://doi.org/10.1038/264767a0
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DOI: https://doi.org/10.1038/264767a0
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