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Letters to Nature
Nature 258, 598-599 (18 December 1975) | doi:10.1038/258598a0; Accepted 30 October 1975
Metal chelate affinity chromatography, a new approach to protein fractionation
JERKER PORATH, JAN CARLSSON, INGMAR OLSSON & GRETA BELFRAGE
- Institute of Biochemistry, University of Uppsala, Sweden and Clinical Research Institute of Montreal, Hormone Laboratory, Montreal, Canada
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Abstract
CONVENTIONAL nonspecific precipitation methods sometimes depend on affinities which can be used in a more selective fashion by modern chromatographic techniques. The affinity of proteins for heavy metal ions, for example, may provide a basis for their purification and analysis. A highly flexible method based on such affinities is described here.
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