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Nature 257, 28 - 32 (04 September 1975); doi:10.1038/257028a0

Three-dimensional model of purple membrane obtained by electron microscopy

R. Henderson & P. N. T. Unwin

MRC Laboratory of Molecular biology, Hills Road, Cambridge CB2 2QH, UK

A 7-Å resolution map of the purple membrane has been obtained by electron microscopy of tilted, unstained specimens. The protein in the membrane contains seven, closely packed, α-helical segments which extend roughly perpendicular to the plane of the membrane for most of its width. Lipid bilayer regions fill the spaces between the protein molecules.

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