Abstract
WE have reported1 an increased response to interferon induction in mice fed a diet containing vitamin C, and have now found a similar phenomenon in vitro. Addition of L-ascorbate to cultures of mouse cells (transformed L cells and normal embryonic fibroblasts) stimulated with polyinosinic acid · polycytidylic acid (poly(rI)·poly(rC)) resulted in increased synthesis of interferon.
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References
Siegel, B. V., Infect. Immun., 10, 409–410 (1974).
Eagle, H., Science, 174, 500–503 (1971).
Finter, N. B., J. gen. Virol., 5, 419–427 (1969).
Burke, D. C., in Interferons and interferon inducers (edit. by Finter, N. B.), 107–133 (North Holland, Amsterdam, London, 1973).
Tan, Y. H., Armstrong, J. H., Ke, Y. H., and Ho, M., Proc. natn. Acad. Sci. U.S.A., 67, 464–471 (1970).
Tomkins, G. M., Levinson, B. B., Baxter, J. D., and Dethlefsen, L., Nature new Biol., 239, 9–13 (1972).
Vilcek, J., and Havell, E. A., Proc. natn. Acad. Sci. U.S.A., 70, 3909–3913 (1973).
Friedman, R. M., and Pastan, I., Biochem. biophys. Res. Commun., 36, 735–740 (1969).
Allen, L. B., et al., Proc. Soc. exp. Biol. Med., 146, 580–584 (1974).
Steiner, A. L., Kipnis, D. M., Utiger, R., and Parker, C., Proc. natn. Acad. Sci. U.S.A., 64, 367–373 (1969).
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SIEGEL, B. Enhancement of interferon production by poly(rI)·poly(rC) in mouse cell cultures by ascorbic acid. Nature 254, 531–532 (1975). https://doi.org/10.1038/254531a0
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DOI: https://doi.org/10.1038/254531a0
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