Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22

Nature volume 251, pages 633–636 (1974)Cite this article

Abstract

PROGRESS in somatic cell genetics now allows more rapid and precise localisation of genes within the human genome. A large number of mouse × human hybrid cell lines are available, permitting the investigator to choose, for phenotype assay, lines with a particular reduced human chromosome complement. An increasingly large number of hybrid lines carrying rearranged chromosomes are also becoming available for regional localisation studies. We have used such hybrid cell lines to assign a gene coding for galactokinase (EC 2.7.1.6) to human chromosome 17 and to further localise the gene to band 21–22 on the long arm of the chromosome. Results from this study have provided new information Regarding the functioning of the genes coding for the Leloir pathway enzymes in man1, and have revealed a relatively close and potentially useful linkage between the genes for galactokinase and for thymidine kinase (EC 2.7.1.21).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cohen, R. M., and Segal, S., Metabolism, 22, 627–642 (1973).

    Article  Google Scholar 

  2. Ruddle, F. H., Nature, 242, 165–169 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Thompson, L. H., Mankovitz, R., Baker, R. M., Wright, J. A., Till, J. E., Sminovitch, L., and Whitmore, G. F., J. Cell Physiol., 78, 431–439 (1971).

    Article  CAS  Google Scholar 

  4. Hauschka, T. S., Weiss, L., Holridge, B. A., Cudney, T. L., Zumpft, M., and Plannsek, J. A., J. natn. Cancer Inst., 47, 343–359 (1971).

    CAS  Google Scholar 

  5. Littlefield, J., Proc. natn. Acad. Sci. U.S.A., 50, 568–576 (1968).

    Article  ADS  Google Scholar 

  6. Tischfield, J. A., and Ruddle, F. H., Proc. natn. Acad. Sci. U.S.A., 71, 45–49 (1974).

    Article  ADS  CAS  Google Scholar 

  7. Hayflick, L., Exp Cell Res., 37, 614–636 (1965).

    Article  CAS  Google Scholar 

  8. McMorris, F. A., thesis, Yale Univ. (1972).

  9. Kit, S., Dubbs, D. R., Pickarski, L. J., and Hsu, T. C., Exp. Cell Res., 31, 297–312 (1963).

    Article  CAS  Google Scholar 

  10. Boone, C., Chen, T.-R., and Ruddle, F. H., Proc. natn. Acad. Sci. U.S.A., 69, 510–514 (1972).

    Article  ADS  CAS  Google Scholar 

  11. McDougall, J. K., Kucherlapati, R., and Ruddle, F. H., Nature new Biol., 245, 172–175 (1973).

    Article  CAS  Google Scholar 

  12. Littlefield, J. W., Science, 145, 709–710 (1964).

    Article  ADS  CAS  Google Scholar 

  13. Miller, O. J., Allerdice, P. W., Miller, D. A., Breg, W. R., and Migeon, B. R., Science, 173, 244–245 (1971).

    Article  ADS  CAS  Google Scholar 

  14. Munyon, W., Buchsbaum, R., Paoletti, E., Mann, J., Kraiselburd, E., and Davis, D., Virology, 49, 683–689 (1972).

    Article  CAS  Google Scholar 

  15. Kit, S., Leung, W.-C., and Kaplan, L. A., Europ. J. Biochem., 39, 43–48 (1973).

    Article  CAS  Google Scholar 

  16. Kucherlapati, R., McDougall, J. K., and Ruddle, F. H., New Haven Conference (1973): First International Workshop on Human Gene Mapping. Birth Defects: Original Article Series, X: 3, 108–110 (National Foundation, New York, 1974).

  17. Nichols, E. A., and Ruddle, F. H., J. Histochem. Cytochem., 21, 1066–1081 (1973).

    Article  CAS  Google Scholar 

  18. Migeon, B. R., Smith, S. W., and Leddy, C. L., Biochem Genet., 3, 583–590 (1969).

    Article  CAS  Google Scholar 

  19. Nichols, E. A., Elsevier, S. M., and Ruddle, F. H., Cytogenet. Cell Genet., 13, 275–278 (1974).

    Article  CAS  Google Scholar 

  20. Blume, K.-G., and Beutler, E., J. biol. Chem., 246, 6507–6510 (1971).

    CAS  PubMed  Google Scholar 

  21. Adhya, S. L., and Shapiro, J. A., Genetics, 62, 231–247 (1961).

    Google Scholar 

  22. Bassel, J., and Mortimer, R., J. Bact., 108, 179–183 (1971).

    CAS  PubMed  Google Scholar 

  23. Sun, N. C., Chang, C. C., and Chu, E. H. Y., Proc. natn. Acad. Sci. U.S.A., 71, 404–407 (1974).

    Article  ADS  CAS  Google Scholar 

  24. Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hungerford, D. A., Exp Cell Res., 20, 613–616 (1960).

    Article  CAS  Google Scholar 

  25. Caspersson, T., Zech, L., Johansson, C., and Modest, B. J., Chromosoma, 30, 215–227 (1970).

    Article  CAS  Google Scholar 

  26. Chen, T.-R., and Ruddle, F. H., Chromosoma, 34, 51–72 (1971).

    Article  CAS  Google Scholar 

  27. Mayes, J. S., and Guthrie, R., Biochem. Genet., 2, 219–230 (1962).

    Article  Google Scholar 

  28. Tischfield, J. A., Bernhard, H.-P., and Ruddle, F. H., Anal. Biochem., 53, 545–554 (1973).

    Article  CAS  Google Scholar 

  29. Paris Conference (1971): Standardization in Human Cytogenetics. Birth Defects: Original Article Series VIII: 7, 18–19 (National Foundation, New York, 1972).

Download references

Author information

Authors and Affiliations

  1. Department of Biology, Yale University, New Haven, Connecticut, 06520

    S. M. ELSEVIER, R. S. KUCHERLAPATI, E. A. NICHOLS, R. P. CREAGAN, R. E. GILES & F. H. RUDDLE

  2. Institute für Genetik, 5 Köln 41, Wyertal, 121, West Germany

    K. WILLECKE

  3. Department of Cancer Studies, University of Birmingham, Birmingham, B15 2TJ, UK

    J. K. McDOUGALL

Authors
  1. S. M. ELSEVIER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. S. KUCHERLAPATI
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. A. NICHOLS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. P. CREAGAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. E. GILES
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. H. RUDDLE
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. K. WILLECKE
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. J. K. McDOUGALL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

ELSEVIER, S., KUCHERLAPATI, R., NICHOLS, E. et al. Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22. Nature 251, 633–636 (1974). https://doi.org/10.1038/251633a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/251633a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing