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Topological comparison of adenyl kinase with other proteins

Nature volume 250, pages 142–144 (1974)Cite this article

Abstract

A COMBINATION of amino acid sequence analysis1 and X-ray analysis has yielded the atomic structure of the enzyme adenyl kinase2 (adenylate kinase, EC 2.7.4.3). No protein of which the structure is known is so closely related to adenyl kinase that an amino acid sequence comparison3 or an exact geometrical comparison of the structures4–6 can be expected to indicate a relationship. Similarities with other proteins become apparent, however, if one restricts the comparison to topologies, that is, to chain folds without reference to the exact geometry. Since chain folds are particularly well conserved during evolution7 such a procedure might reveal distant relationships.

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References

  1. Heil, A., Müller, G., Noda, L. H., Pinder, T., Schirmer, I., Schirmer, R. H., and v. Zabern, I., Eur. J. Biochem., 43, 131–144 (1974).

    Article  CAS  Google Scholar 

  2. Schulz, G. E., Elzinga, M., Marx, F., and Schirmer, R. H., Nature, 250, 120–123 (1974).

    Article  ADS  CAS  Google Scholar 

  3. Dayhoff, M. O., Atlas of Protein Sequence and Structure, 5, (National Biochemical Research Foundation, Washington DC, 1972).

    Google Scholar 

  4. McLachlan, A. D., Nature New Biol., 240, 83–85 (1972).

    Article  CAS  Google Scholar 

  5. Rao, S. T., and Rossmann, M. G., J. molec. Biol., 76, 241–256 (1973).

    Article  CAS  Google Scholar 

  6. Rossmann, M. G., Liljas, A., J. molec. Biol., 85, 177–181 (1974).

    Article  Google Scholar 

  7. Timkovich, R., and Dickerson, R. E., J. molec. Biol., 79, 39–56 (1973).

    Article  CAS  Google Scholar 

  8. Schubert Wright, C., Alden, R. A., Kraut, J., Nature, 221, 235–242 (1969).

    Article  ADS  Google Scholar 

  9. Drenth, J., Hol, W. G. J., Jansonius, J. N., and Koekoek, R., Cold Spring Harbor Symp. quant. Biol., 36, 107–116 (1971).

    Article  CAS  Google Scholar 

  10. Kraut, J., Robertus, J. D., Birktoft, J. J., Alden, R. A., Wilcox, P. E., and Powers, J. C., Cold Spring Harbor Symp. quant. Biol., 36, 117–123 (1971).

    Article  CAS  Google Scholar 

  11. Watenpaugh, K. D., Sieker, L. C., Jensen, L. H., Legall, J., and Dubourdieu, M., Proc. natn. Acad. Sci. U.S.A., 69, 3185–3188 (1972).

    Article  ADS  CAS  Google Scholar 

  12. Andersen, R. D., Apgar, P. A., Burnett, R. M., Darling, G. D., Lequesne, M. E., Mayhew, S. G., and Ludwig, M. L., Proc. natn. Acad. Sci. U.S.A., 69, 3189–3191 (1972).

    Article  ADS  CAS  Google Scholar 

  13. Rossmann, M. G., Adams, M. J., Buehner, M., Ford, G. C., Hackert, M. L., Lentz, jun., P. J., McPherson, jun., A., Schevitz, R. W., and Smiley, I. E., Cold Spring Harbor Symp. quant. Biol., 36, 179–191 (1971).

    Article  CAS  Google Scholar 

  14. Hill, E., Tsernoglou, D., Webb, L., and Banaszak, L. J., J. molec. Biol., 72, 577–591 (1972).

    Article  CAS  Google Scholar 

  15. Brändén, C. I., Eklund, H., Nordström, B., Boiwe, T., Söderlund, G., Zeppezauer, E., Ohlsson, I., and Åkeson, Å., Proc. natn. Acad. Sci. U.S.A., 70, 2439–2442 (1973).

    Article  ADS  Google Scholar 

  16. Buehner, M., Ford, G. C., Moras, D., Olsen, K. W., and Rossmann, M. G., Proc. natn. Acad. Sci. U.S.A., 70, 3052–3054 (1973).

    Article  ADS  CAS  Google Scholar 

  17. Blake, C. C. F., and Evans, P. R., J. molec. Biol., 84, 585–601 (1974).

    Article  CAS  Google Scholar 

  18. Wetlaufer, D. B., Proc. natn. Acad. Sci. U.S.A., 70, 697–701 (1973).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Max-Planck-Institut für medizinische Forschung, Heidelberg, Federal Republic of Germany

    G. E. SCHULZ & R. H. SCHIRMER

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  1. G. E. SCHULZ
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  2. R. H. SCHIRMER
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SCHULZ, G., SCHIRMER, R. Topological comparison of adenyl kinase with other proteins. Nature 250, 142–144 (1974). https://doi.org/10.1038/250142a0

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