Abstract
THE stabilities of interferons vary widely, depending on their source and degree of contamination. Even relatively stable interferons seem to become labile as various degrees of purity are attained1. In the absence of a more suitable means of stabilisation, some investigators rely on addition of extraneous protein to stabilise interferons during purification2, thus, a method for stabilising interferons would have considerable value.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Ng, N. H., and Vilcek, J., Adv. Protein Chem., 26, 173–241 (1972).
Stancek, D., and Paucker, K., Acta virol., 14, 125–134 (1970).
Tanford, C., Adv. Protein Chem., 23, 121–282 (1968).
Weil, R., and Dorner, F., in Selective inhibitors of viral functions (edit. by Carter, W. D.) 107–121 (CRC Press, Cleveland, 1973).
Maizel, J. V., jun., in Methods in Virology (edit. by Koprowski, H. and Maramorosch, K.) 179–246 (Academic New York 1970).
Tanford, C., Adv. Protein Chem., 24, 1 95 (1970).
Ray, A., Reynolds, J., Polet, H., and Steinhardt, J., Biochemistry, 5, 2606–2617 (1966).
Stewart, W. E. II, De Clercq, E., De Somer, P., Berg, K., Ogburn, C. A., and Paucker, K., Nature new Biol., 246, 141–143 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STEWART, W., DE CLERCQ, E. & DE SOMER, P. Stabilisation of interferons by defensive reversible denaturation. Nature 249, 460–461 (1974). https://doi.org/10.1038/249460a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/249460a0
This article is cited by
-
Expression of human fibroblast interferon gene in Escherichia coli
Nature (1980)
-
The reactivation of human interferons by guanidine thiocyanate
Experientia (1980)
-
Monkey interferon: Activity on human cells and chromatographic properties
Archives of Virology (1979)
-
Resolution of human fibroblast interferon into two distinct classes by thiol exchange chromatography
Archives of Virology (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
