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Letters to Nature
Nature 249, 459 - 460 (31 May 1974); doi:10.1038/249459a0

Immunosuppression detected in pregnant mice by rosette inhibition test


Department of Surgery, University of Queensland at the Princess Alexandra Hospital, Brisbane, 4102 Australia

ATTENTION has recently been drawn to the immunological mechanisms concerned in the nonrecognition of the antigenic status of the foetus during uterine life. Several workers1–3 have demonstrated that lymphocyte transformation is suppressed during pregnancy. As the rosette inhibition test4 has been used to show that the lymphocyte activity in vivo is modified by immunosuppressive therapy following trasnplantation5, it suggests that this technique could also be used to investigate possible immunosuppression during pregnancy.



1. Purtilo, D. T., Hallgren, H. M., and Yunis, E. J., Lancet, i, 769 (1972).
2. Finn, R., St. Hill, C. A., Govan, A. J., Ralfs, I. G., Gurney, F. J., and Denye, V., Br. med. J., 3, 150 (1972).
3. Contractor, S. F., and Davies, H., Nature new Biol., 243, 284 (1973).
4. Bach, J. F., Dormont, J., Dardenne, M., and Balner, H., Transplantation, 8, 265 (1969).
5. Munro, A., Bewick, M., Manuel, L., Cameron, J. S., Ellis, F. G., Boulton-Jones, M., and Ogg, C. S., Br. med. J., 3, 271 (1971).
6. Morton, H., Hegh, V., and Clunie, G. J. A., Clin. exp. Immun., 13, 595 (1973).

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