Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Friday 20 October 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Letters to Nature
Nature 248, 588 - 590 (12 April 1974); doi:10.1038/248588a0

Zinc ions inhibit replication of rhinoviruses

B. D. KORANT, J. C. KAUER & B. E. BUTTERWORTH

Central Research Department, E. I. du Pont de Nemours and Company, Experimental Station, Wilmington, Delaware 19898

THE rhinoviruses comprise a subgroup of the picornaviruses, distinguished by their acid lability. They are medically important as the infectious agents of the common cold in man. Although there have been reports of chemical agents which inhibit rhinovirus replication, in only a few instances has the mode of antiviral action been demonstrated at a biochemical level1,2.

------------------

References

1. Schleicher, J. B., Aquino, F. A., Rueter, A., Roderick, W. R., and Appell, R. N., Abstr. Tenth Interscience Conf. Antimicrobial Agents and Chemotherapy, Chicago, Abstr. No. 99 (1970).
2. Matsumoto, S., Stanfield, F. J., Goore, M. Y., and Haff, R. F., Proc. Soc. exp. biol. Med., 139, 455 (1972).
3. Vallee, B. L.,and Wacker, W. E. C., in The Proteins (edit. by Neurath, H.), 5, No. 22, 143 (Academic Press, New York, 1972).
4. Hughes, M. N., The Inorganic Chemistry of Biological Processes (Wiley, London, 1972).
5. Korant, B. D., Lonberg-Holm, K., Noble, J., and Stasny, J. T., Virology, 48, 71 (1972).
6. Medappa, K. C., McLean, C., and Rueckert, R. R., Virology, 44, 259 (1971).
7. McLean, C., and Rueckert, R. R., J. Virol., 11, 341 (1973).
8. Butterworth, B. E., Virology, 56, 439 (1973).
9. Reviewed by Sugiyama, T., Korant, B. D., and Lonberg-Holm, K. K., A. Rev. Microbiol., 26, 467 (1972).
10. Laemmli, U. K., Nature, 227, 680 (1970).
11. Vogt, V. M., and Eisenman, R., Proc. natn. Acad., Sci. U.S.A., 70, 1734 (1973).
12. Korant, B. D., J. Virol., 10, 751 (1972).
13. Summers, D. F., Shaw, E., Stewart, M. L.,and Maizel, J. V., J. Virol., 10, 880 (1972).
14. Korant, B. D., J. Virol., 12, 556 (1973).



© 1974 Nature Publishing Group
Privacy Policy