Abstract
CIRCADIAN rhythms in susceptibility to drugs are well documented, both in laboratory animals and man, and as a consequence the concepts of circadian chronopharmacology, chronotoxicology and chronotherapy have developed1. Although there is a most marked circadian rhythm in the incidence of spontaneous delivery in women2, there appear to have been no studies of the chronopharmacology of drugs, such as oxytocin and the prostaglandins, used in the induction of labour or abortion.
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References
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SMITH, I., SHEARMAN, R. & KORDA, A. Chronoperiodicity in the Response to the Intra-amniotic Injection of Prostaglandin F2α in the Human. Nature 241, 279–280 (1973). https://doi.org/10.1038/241279a0
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DOI: https://doi.org/10.1038/241279a0
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