Nature 240, 225 - 228 (24 November 1972); doi:10.1038/240225a0

Genes Coding for Polysomal 9S RNA of Sea Urchins: Conservation and Divergence

E. S. WEINBERG^*, M. L. BIRNSTIEL^*, I. F. PURDOM^* & R. WILLIAMSON^†

^*MRC Epigenetics Research Group, Department of Genetics, University of Edinburgh
^†The Beatson Institute for Cancer Research, Glasgow

The DNA sequences coding for the individual major subfractions of the putative histone mRNAs are all 1,200-fold reiterated and are contained in a "cryptic" density satellite in Psam-mechinus DNA. While random mutational drift cannot be detected in the 9S mRNA coding sequences within the species, it is very much in evidence during the evolution of two related sea urchin species.

References

1.	Nemer, M., and Infante, A. A., Science, 150, 217 (1965).
2.	Kedes, L. H., and Gross, P. R., Nature, 223, 1335 (1969).
3.	Kedes, L. H., and Gross, P. R., J. Mol. Biol., 42, 559 (1969).
4.	Nemer, M., and Lindsay, D. T., Biochem. Biophys. Res. Comm., 35, 156 (1969).
5.	Kedes, L. H., Gross, P. R., Cognetti, G., and Hunter, A. L., J. Mol. Biol., 45, 337 (1969).
6.	Moav, B., and Nemer, M., Biochemistry, 10, 881 (1971).
7.	Jacobs-Lorena, M., Borum, T. W., and Baglioni, C. (in the press).
8.	Walker, P. M. B., Progr. Biophys. Mol. Biol., 23, 5 (1971).
9.	Kedes, L. H., and Birnstiel, M. L., Nature New Biology, 230, 165 (1971).
10.	Melli, M. L., Whitfield, C., Rao, K. V., Richardson, M., and Bishop, J. O., Nature New Biology, 231, 8 (1971).
11.	Pardue, M. L., Weinberg, E., Kedes, L. H., and Birnstiel, M. L. (in preparation).
12.	Marmur, J., and Doty, P., J. Mol. Biol., 5, 109 (1962).
13.	Ts'o, P. O. P., Helkamp, G. K., and Sander, C., Proc. US Nat. Acad. Sci., 48, 687 (1962).
14.	Birnstiel, M. L., Sells, B. H., and Purdom, I. F., J. Mol. Biol., 63, 21 (1972).
15.	Kimura, M., Genet. Res., 11, 247 (1968).
16.	Walker, P. M. B., Progr. Nucl. Acid. Res. Mol. Biol., 9, 301 (1969).
17.	Hnilica, L. S., Prog. Nucl. Acid. Res. Mol. Biol., 7, 25 (1967).
18.	Southern, E., Nature New Biology, 232, 82 (1971).
19.	McCarthy, B. J., and Farquhar, M. N., Brookhaven Symposium (1971).
20.	King, J. L., and Jukes, T. H., Science, 164, 778 (1969).
21.	Laird, C. D., McConaughy, B. L., and McCarthy, B. J., Nature, 224, 149 (1969).
22.	Gillespie, E., and Spiegelman, S., J. Mol. Biol., 12, 829 (1972).
23.	Birnstiel, M. L., Speirs, J., Purdom, I., Jones, K., and Loening, U. E., Nature, 219, 454 (1968).
24.	Loening, U. E., Biochem. J., 113, 131 (1969).