Nature 239, 87 - 89 (08 September 1972); doi:10.1038/239087a0

Stability of X Chromosomal Inactivation in Human Somatic Cells

BARBARA RUBEN MIGEON

Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Using human somatic cell/mouse cell hybrids, no evidence for reactivation of the silent X chromosome in human somatic cells has been obtained.

References

1.	Lyon, M., Amer. J. Human Genet., 14, 135 (1962).
2.	Lyon, M. F., Nature New Biology, 232, 229 (1971).
3.	Comings, D. E., Lancet, ii, 1137 (1966).
4.	Davidson, R. G., Nitowsky, H. M., and Childs, B., Proc. US Nat. Acad. Sci., 50, 481 (1963).
5.	Harris, H., Watkins, J. F., Ford, C. E., and Schoefl, G. I., J. Cell Sci., 1, 1 (1966).
6.	Littlefield, J. W., Nature, 203, 1142 (1964).
7.	Szybalski, E. H., and Ragni, G., Nat. Cancer Inst. Monog., No. 7, 75 (1962).
8.	Siniscalco, M., Klinger, H. P., Eagle, H., Koprowski, H., Fujimoto, W. Y., and Seegmiller, J. E., Proc. US Nat. Acad. Sci., 62, 793 (1969).
9.	Porter, I. H., Boyer, S. H., Watson-Williams, E. J., Adam, A., Szeinberg, A., and Siniscalco, M., Lancet, i, 895 (1964).
10.	Migeon, B. R., and Miller, C. S., Science, 162, 1005 (1968).
11.	Green, H., Wang, R., Kehinde, R., and Meuth, M., Nature New Biology, 234, 138 (1971).
12.	Epstein, C. J., Science, 163, 1078 (1969).
13.	Migeon, B. R., Biochem. Genet., 4, 387 (1970).
14.	Nyhan, W. L., Bakayk B., Connor, J. D., Marks, J. F., and Keele, D. K., Proc. US Nat. Acad. Sci., 65, 214 (1970).
15.	Goldstein, J. L., Marks, J. F., and Gartler, S. M., Proc. US Nat. Acad. Sci., 68, 1425 (1971).
16.	Bürk, R. R., Pitts, J. D., and Subak-Sharpe, J. H., Exp. Cell Res., 53, 297 (1968).
17.	Albertini, R. J., and DeMars, R., Science, 169, 482 (1970).
18.	Gartler, S. M., Chen, S.-H., Fialkow, P. J., and Giblett, E. R., Nature New Biology, 236, 149 (1972).
19.	Stern, C., Genetics, 62, 573 (1969).