Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Serum Enzyme Changes during Sleep Deprivation

Nature volume 228, pages 768–770 (1970)Cite this article

Abstract

SUBSTANTIAL increases in serum creatinine phosphokinase (CPK) and aldolase activities occur in many acutely psychotic patients1–3. Futher investigation has shown a frequent but not invariant relationship between sleep disturbance and the serum CPK (and aldolase) activity in acutely psychotic patients4. In eight acutely psychotic patients, severe sleep disruption, often amounting to total insomnia with particular reductions in rapid eye movement (REM) sleep5, was associated with high serum CPK activity. We now report that elevated serum CPK activity and aldolase activity occur in normal subjects during and after experimental sleep deprivation, though many characteristics of these increases in enzyme activity are different from those in acutely psychotic patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Meltzer, H. Y., Science, 159, 1368 (1968).

    Article  ADS  CAS  Google Scholar 

  2. Meltzer, H., Elkun, L., and Moline, R., Arch. Gen. Psychiat., 21, 731 (1969).

    Article  CAS  Google Scholar 

  3. Bengzon, A., Hippius, H., and Kanig, K., J. Nerv. Ment. Dis., 143, 369 (1966).

    Article  CAS  Google Scholar 

  4. Meltzer, H., Kupfer, D., Wyatt, R., and Snyder, F., Arch. Gen. Psychiat., 22, 398 (1970).

    Article  CAS  Google Scholar 

  5. Kupfer, D. J., Wyatt, R. J., Scott, J., and Snyder, F., Amer. J. Psychiat., 126, 1213 (1970).

    Article  CAS  Google Scholar 

  6. Rosalki, S. B., J. Lab. Clin. Med., 69, 696 (1967).

    CAS  PubMed  Google Scholar 

  7. Fruns, F., Biochem. Z., 325, 156 (1954).

    Google Scholar 

  8. Thompson, W. H. S., Clin. Chim. Acta, 21, 469 (1968).

    Article  Google Scholar 

  9. Kalliomaki, J. L., Laine, V. A. I., and Ruutsalo, H. M., Acta Rheum. Scand., 14, 185 (1968).

    Article  CAS  Google Scholar 

  10. Fowler, W. M., Chowdhury, S. R., Pearson, C. M., Gardner, G., and Bratton, R., J. Appl. Physiol., 17, 943 (1962).

    Article  CAS  Google Scholar 

  11. Ahlborg, B., and Brohult, J., Forsvarsmedicine, 2, 35 (1966).

    Google Scholar 

  12. Griffiths, P. D., Clin. Chim. Acta, 13, 413 (1966).

    Article  CAS  Google Scholar 

  13. Meltzer, H., and Moline, R., Arch. Gen. Psychiat. (in the press).

  14. Polis, B. D., Polis, E., DeCani, J., Schwarz, H. P., and Dreisbach, L., Biochem. Med., 2, 286 (1969).

    Article  CAS  Google Scholar 

  15. Kollar, E. J., Pasnan, R. O., Rubin, R. T., Naitoh, P., Slater, G. G., and Kales, A., Amer. J. Psychiat., 126, 70 (1969).

    Article  Google Scholar 

  16. Bennert, H. W., and Betts, A., J. Maine Med. Ass., 58, 214 (1967).

    PubMed  Google Scholar 

  17. Meltzer, H., Arch. Gen. Psychiat., 21, 102 (1969).

    Article  CAS  Google Scholar 

  18. Thomson, W. H. S., Adv. Clin. Chem., 7, 137 (1964).

    Article  CAS  Google Scholar 

  19. Eschar, J., and Zimmerman, H. J., Amer. J. Med. Sci., 48, 272 (1967).

    Google Scholar 

  20. Sibley, J. A., and Fleisher, G. A., Proc. Mayo Clin., 29, 591 (1959).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, 06510

    DAVID J. KUPFER

  2. Department of Psychiatry, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, 60637

    HERBERT Y. MELTZER

  3. Laboratory of Clinical Psychopharmacology, National Institute of Mental Health, Washington DC, 20014

    RICHARD J. WYATT

  4. Laboratory of Clinical Psychobiology, National Institute of Mental Health, Bethesda, Maryland, 20014

    FREDERICK SNYDER

Authors
  1. DAVID J. KUPFER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HERBERT Y. MELTZER
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. RICHARD J. WYATT
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. FREDERICK SNYDER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KUPFER, D., MELTZER, H., WYATT, R. et al. Serum Enzyme Changes during Sleep Deprivation. Nature 228, 768–770 (1970). https://doi.org/10.1038/228768a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/228768a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing