Nature 228, 684 - 685 (14 November 1970); doi:10.1038/228684a0

Mode of Action of the Anthelminthic Thiabendazole in Haemonchus contortus

R. K. PRICHARD

Division of Animal Health, CSIRO, McMaster Laboratory, Glebe, New South Wales.

THIABENDAZOLE, 2,4'-thiazolyl benzimidazole, is an efficient, non-toxic, broad spectrum anthelminthic¹ and antifungal agent². Its mode of action is not known, although its properties as a chelating agent have been noted³.

References

1.	Brown, H. D., Matzuk, A. R., Ilves, I. R., Peterson, L. H., Harris, S. A., Sarett, L. H., Egerton, J. R., Yakstis, J. J., Campbell, W. C., and Cuckler, A. C., J. Amer. Chem. Soc., 83, 1764 (1961).
2.	Robinson, H. J., Phares, H. F., and Graessle, O. E., J. Invest. Dermatol., 42, 479 (1964).
3.	Robinson, H. J., Stoerk, H. C., and Graessle, O. E., Toxic. Appl. Pharmacol., 7, 53 (1965).
4.	Kmetec, E., and Bueding, E., J. Biol. Chem., 236, 584 (1961).
5.	Cheah, K. S., and Bryant, C., Comp. Biochem. Physiol., 19, 197 (1966).
6.	Scheibel, L. W., Saz, H. J., and Bueding, E., J. Biol. Chem., 243, 2229 (1968).
7.	Prichard, R. K., and Schofield, P. J., Comp. Biochem. Physiol., 25, 1005 (1968).
8.	Seidman, I., and Entner, N., J. Biol. Chem., 236, 915 (1961).
9.	Fischerova, H., and Kubistova, J., Exp. Parasitol., 23, 244 (1968).
10.	De Zoeten, L. W., and Tipker, J., Z. Physiol. Chemie, 350, 691 (1969).
11.	Van den Bossche, H., and Jansen, P. A. J., Biochem. Pharmacol., 18, 35 (1969).