Nature 228, 27 - 30 (03 October 1970); doi:10.1038/228027a0

Interferon Production by T4 Coliphage

W. J. KLEINSCHMIDT, R. J. DOUTHART & E. B. MURPHY

The Lilly Research Laboratories, Indianapolis, Indiana 46206

Evidence is presented that DNA can act as an inducer of interferon.

References

1.	Kleinschmidt, W. J., and Ellis, L. F., in Ciba Symposium on Interferon (edit. by Wolstenholme, G. E., and O'Connor, M.), 39 (Churchill, London, 1967).
2.	Ellis, L. F., and Kleinschmidt, W. J., Nature, 215, 649 (1967).
3.	Lampson, G. P., Tytell, A. A., Field, A. K., Nemes, M. M., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 782 (1967).
4.	Kleinschmidt, W. J., Ellis, L. F., Van Frank, R. M., and Murphy, E. B., Nature, 220, 167 (1968).
5.	Banks, G. T., Bucks, K. W., Chain, E. B., Himmelweit, F., Marks, J. E., Tyler, J. M., Hollings, M., Last, F. T., and Stone, O. M., Nature, 218, 542 (1968).
6.	Field, A. K., Tytell, A. A., Lampson, G. P., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 1004 (1967).
7.	Colby, C., and Chamberlin, M. J., Proc. US Nat. Acad. Sci., 63, 160 (1970).
8.	Friend, D. S., Rosenau, W., Winfield, I. S., and Moon, H. D., Lab. Invest., 20, 275 (1969).
9.	Fraser, D., and Jerrel, E. A., J. Biol. Chem., 205, 291 (1953).
10.	Adams, M. H., Bacteriophages (Interscience, New York, 1959).
11.	Youngner, J. S., and Stinebring, W. R., Nature, 208, 456 (1965).
12.	Herriott, R. M., and Barlow, J. L., J. Gen. Physiol., 40, 809 (1957).
13.	Hayes, W., in The Genetics of Bacteria and Their Viruses, 376 (Wiley, New York, 1965).
14.	Maestre, M. F., and Tinoco, jun., I., J. Mol. Biol., 23, 323 (1967).
15.	Colby, C., and Duesberg, P. H., Nature, 222, 940 (1969).
16.	Jurale, C., Kates, J. R., and Colby, C., Nature, 226, 1027 (1970).
17.	DeClercq, E., Wells, R. D., and Merigan, T. C., Nature, 226, 364 (1970).