Nature 228, 25 - 27 (03 October 1970); doi:10.1038/228025a0

Homotypic and Heterotypic Interference by Defective Particles of Vesicular Stomatitis Virus

LUDVIK PREVEC & CHIL YONG KANG

Department of Biology, McMaster University, Hamilton, Ontario

Defective particles can serve as templates for their replication by helper infectious virus. While both the "long T" and "short T" defective particles in VSV preparations are capable of homotypic interference, only the larger "long T" particle is capable of heterotypic interference.

References

1.	Uchida, S., and Watanabe, S., Virology, 39, 721 (1969).
2.	Parks, W. P., Casazza, A. M., Alcott, J., and Melnick, J. L., J. Exp. Med., 127, 91 (1968).
3.	Pons, M., and Hirst, G. K., Virology, 38, 68 (1969).
4.	Huang, A. S., and Baltimore, D., Nature, 226, 325 (1970).
5.	Huang, A. S., and Wagner, R. R., Virology, 30, 173 (1966).
6.	Hackett, A. J., Schaffer, E. L., and Madin, S. H., Virology, 31, 114 (1967).
7.	Crick, J., Cartwright, B., and Brown, F., Nature, 211, 1204 (1966).
8.	Huang, A. S., Greenawalt, J. W., and Wagner, R. R., Virology, 30, 161 (1966).
9.	Petric, M., and Prevec, L., Virology, 41, 615 (1970).
10.	Kang, C. Y., and Prevec, L., J. Virol., 3, 404 (1969).
11.	Wagner, R. R., Schnaitman, J. A., and Snyder, R. M., J. Virol., 3, 395 (1969).
12.	Huang, A. S., and Wagner, R. R., J. Mol. Biol., 22, 381 (1966).
13.	Nakai, T., and Howatson, A. F., Virology, 35, 268 (1968).
14.	Stampfer, M., Baltimore, D., and Huang, A. S., J. Virol., 2, 154 (1969).
15.	Kang, C. Y., and Prevec, L., J. Virol., 6, 22 (1970).
16.	Baltimore, D., Huang, A. S., and Stampfer, M., Proc. US Nat. Acad. Sci., 66 (1970).
17.	Bellett, A. D. J., and Cooper, P. D., J. Gen. Microbiol., 21, 498 (1959).