Abstract
Soluble cell membrane extracts of liver and spleen have been injected intravenously at the time of renal allografting. In dogs and rhesus monkeys there was slight prolongation of transplant survival in some experiments. Survival was markedly prolonged in 30 per cent of pigs, however. Donor blood and serum had a similar effect in protecting porcine liver allografts from rejection.
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References
Moore, F. D., Brownell Wheeler, H., Demissianos, H. V., Smith, L. L., Balankura, O., Abel, K., Greenberg, J. B., and Dammin, G. J., Ann. Surg., 152, 374 (1960).
Starzl, T. E., Marchioro, T. L., Porter, K. A., Taylor, P. D., Faris, T. D., Herrmann, T. J., Hlad, C. J., and Waddell, W. R., Surgery, 58, 131 (1965).
Lee, S., and Edgington, T., Amer. J. Pathol., 52, 649 (1968).
Hunt, A. C., The Liver (edit. by Read, A. E.), Colston Papers No. 19, 337 (Butterworths, 1967).
Mieny, C. J., Moore, A. R., Homatas, J., and Eiseman, B., S. Afric. J. Surg., 5, 109 (1967).
Garnier, H., Clot, J. P., and Chomette, G., Surg. Gynec. Obstet., 130, 105 (1970).
Starzl, T. E., in Experience in Hepatic Transplantation, 188 (Saunders, Philadelphia, 1969).
Calne, R. Y., Davis, D. R., Pena, J. R., Balner, H., De Vries, M., Herbertson, B. M., Joysey, V. C., Millard, P. R., Seaman, M. J., Samuel, J. R., Stibbe, J., and Westbroek, D. L., Lancet, i, 103 (1970).
Calne, R. Y., Williams, R., Dawson, J. L., Ansell, I. D., Evans, D. B., Flute, P. T., Herbertson, B. M., Joysey, V., Keates, G. H. W., Knill-Jones, R. P., Mason, S. A., Millard, P. R., Pena, J. R., Pentlow, B. D., Salaman, J. R., Sells, R. A., and Cullum, P. A., Brit. Med. J., 4, 541 (1968).
Calne, R. Y., White, H. J. O., Yoffa, D. E., Maginn, R. R., Binns, R. M., Samuel, J. R., and Molina, V. P., Brit. Med. J., 2, 478 (1967).
Calne, R. Y., White, H. J. O., Binns, R. M., Herbertson, B. M., Millard, P. R., Pena, J., Salaman, J. R., Samuel, J. R., and Davis, D. R., Trans. Proc., 1, 321 (1969).
Calne, R. Y., Sells, R. A., Pena, J. R., Davis, D. R., Millard, P. R., Herbertson, B. M., Binns, R. M., and Davies, D. A. L., Nature, 223, 472 (1969).
Festenstein, H., Transplant. Rev., 3, 93 (1970).
Viza, D., Sugar, R., and Binns, R. M., Nature, 227, 949 (1970).
Wilson, D. B., Silvers, W. K., and Nowell, P. C., J. Exp. Med., 126, 655 (1967).
Schwarz, M. R., J. Exp. Med., 127, 879 (1968).
Simonsen, M., Transplant. Rev., 3, 22 (1970).
Stuart, F. P., Saitoh, R., and Fitch, F. W., Science, 160, 1463 (1968).
Sheil, A. G. R., Mitchell, R. M., Dammin, G. J., and Murray, J. E., in Adv. Transplant., 599 (Munksgaard, Copenhagen, 1967).
Zeiss, I. M., Immunology, 17, 517 (1969).
Van Rood, J. J., Van Leeuwen, A., and Van Santen, M. C. T., Nature, 226, 366 (1970).
Davies, D. A. L., Immunology, 11, 115 (1966).
Davies, D. A. L., Transplantation, 5, 31 (1967).
Davies, D. A. L., Transplantation, 8, 51 (1969).
Colombani, J., Colombani, M., Viza, D. C., Degani-Bernard, O., Dausset, J., and Davies, D. A. L., Transplantation, 9, 228 (1970).
Calne, R. Y., Ann. Roy. Coll. Surg., 42, 283 (1968).
Binns, R. M., and Hall, J. G., Brit. J. Exp. Pathol., 47, 275 (1966).
Hunt, A. C., Brit. J. Exp. Pathol., 49, 338 (1968).
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CALNE, R., DAVIS, D., HADJIYANNAKIS, E. et al. Immunosuppressive Effects of Soluble Cell Membrane Fractions, Donor Blood and Serum on Renal Allograft Survival. Nature 227, 903–906 (1970). https://doi.org/10.1038/227903a0
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DOI: https://doi.org/10.1038/227903a0
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