Nature 227, 563 - 567 (08 August 1970); doi:10.1038/227563a0

Characterization of the Products of RNA-directed DNA Polymerases in Oncogenic RNA Viruses

S. SPIEGELMAN, A. BURNY, M. R. DAS, J. KEYDAR, J. SCHLOM, M. TRAVNICEK & K. WATSON

Institute of Cancer Research, Columbia University, and College of Physicians and Surgeons, 99 Fort Washington Avenue, New York, NY 10032

Several RNA tumour viruses contain an enzyme that synthesizes a DNA−RNA hybrid using the single stranded viral RNA as template. Hybridization experiments confirm that the DNA strand is complementary to the viral RNA.

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