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Letters to Nature
Nature 227, 168 - 170 (11 July 1970); doi:10.1038/227168a0

Characteristics of a Human Diploid Cell Designated MRC-5

J. P. JACOBS*, C. M. JONES* & J. P. BAILLE*

*National Institute for Medical Research, Holly Hill, London NW3.

THE stability and integrity of the human foetal cell strain WI-38, which has been well demonstrated in the past ten years1–3, and its susceptibility to viruses infective for man1,4, explain the value of such material for the isolation of viruses and in the development of vaccines5–8. We have developed another strain of cells, also derived from foetal lung tissue, taken from a 14-week male foetus removed for psychiatric reasons from a 27 year old woman with a genetically normal family history and no sign of neoplastic disease both at abortion and for at least three years afterwards. The criteria used for characterizing the cells are those recommended internationally2,9.

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References

1. Hayflick, L., and Moorhead, P. S., Exp. Cell. Res., 25, 585 (1961).
2. Minutes Fifth Meeting Committee on Cell Cultures, Permanent Section on Microbiological Standardization, 40 (Intern. Assoc. Microbiol. Socs., 1968).
3. Trlifajova, J., and Strizova, V., J. Hyg. Epidemiol. Microbiol. Immunol., 10, 510 (1966).
4. Herrman, jun., E. C., Amer. J. Epidemiol., 85, 200 (1967).
5. Hayflick, L., Plotkin, S. A., Norton, T. W., and Koprowski, H., Amer. J. Hyg., 75, 240 (1962).
6. Ikie, D., Prog. Immunobiol., 2, 305 (1965).
7. Chanock, R. M., Ludwig, W., Huebner, R. J., Cate, T. R., and Liang-Wei Chu, J. Amer. Med. Assoc., 195, 445 (1966).
8. Plotkin, S. A., Farquhar, J., Katz, M., and Ingalls, T., Amer. J. Epidemiol., 86, 468 (1967).
9. Proc. Symp. on Characterization and Uses of Human Diploid Cell Strains, Opatija, Yugoslavia, 1963, 709).
10. McCarthy, K., Taylor-Robinson, C. H., and Pillinger, S. E., Lancet, ii, 593 (1963).



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