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Nature 226, 1209 - 1211 (27 June 1970); doi:10.1038/2261209a0

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

DAVID BALTIMORE

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.

Two independent groups of investigators have found evidence of an enzyme in virions of RNA tumour viruses which synthesizes DNA from an RNA template. This discovery, if upheld, will have important implications not only for carcinogenesis by RNA viruses but also for the general understanding of genetic transcription: apparently the classical process of information transfer from DNA to RNA can be inverted.

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