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Effect of Thymine Concentration on the Replication Velocity of DNA in a Thymineless Mutant of Escherichia coli

Abstract

Changes in thymine concentration in the growth medium affect the chromosome replication time of thymineless cells. This alone may account for changes in cell composition and provide a demonstration of the absence of coupling between replication velocity and growth rate.

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PRITCHARD, R., ZARITSKY, A. Effect of Thymine Concentration on the Replication Velocity of DNA in a Thymineless Mutant of Escherichia coli. Nature 226, 126–131 (1970). https://doi.org/10.1038/226126a0

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