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Letters to Nature
Nature 225, 651 - 652 (14 February 1970); doi:10.1038/225651a0

Investigation of p-Methoxyamphetamine Excretion in Amphetamine Induced Psychosis

B. M. ANGRIST, J. W. SCHWEITZER, A. J. FRIEDHOFF & S. GERSHON

Department of Psychiatry and Neurology, New York University School of Medicine, 550 First Avenue, New York.

MANY differences exist between the symptoms of schizophrenia and those of drug-induced states caused by agents like LSD or mescaline1. Amphetamine psychosis, by contrast, can in some cases replicate virtually all of the manifestations of natural schizophrenic illness2−5. Such a correspondence justifies a study of the biochemical basis of this condition.

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References
1. Hollister, L., Chemical Psychosis, LSD and Related Drugs, 117 (Thomas, Springfield, 1968).
2. Connell, P. H., Amphetamine Psychosis, Maudsley Monographs, No. 5, 75 (Oxford University Press, London, 1958).
3. Griffith, J. J., Oates, J., and Cauanaugh, J., J. Amer. Med. Assoc., 205, 39 (1968).
4. Angrist, B. M., and Gershon, S., Schizophrenia. Current Concepts and Research (edit. by Siva Sankar, D. V.), 508 (P. J. D. Publications Ltd, 1969).
5. Angrist, B. M., and Gershon, S., Proc. Soc. Biol. Psychiat., 1970 (in the press).
6. Smythies, J. R., Johnston, U. S., Bradley, R. J., Bennington, F., Morin, R. D., and Clark, jun., L. C., Nature, 216, 128 (1967).
7. Smythies, J. R., Copper, A., and Kreitman, N., Biological Psychiatry, A Review of Recent Advances, 70 (Springer-Verlag, New York, 1968).
8. Shulgin, A. T., Sargent, T., and Naranjo, C., Nature, 221, 537 (1969).
9. Angrist, B. M., Schweitzer, J. W., Friedhoff, A. J., Gershon, S., Hekimian, L. J., and Floyd, A., Internal. Pharmacopsychiat., 2, 125 (1969).



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