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Article
Nature 224, 331 - 335 (25 October 1969); doi:10.1038/224331a0

Initiator Protein Dependent Binding of Messenger RNA to Ribosomes

HAIM GREENSHPAN & MICHEL REVEL

Department of Biochemistry, Weizmann Institute of Science, Rehovot, Israel

With isolated 30S ribosomal subunits, binding of T4 mRNA is dependent on initiation factors in the absence of formyl Met-tRNAf. Formation of the 70S–mRNA complex, however, occurs only when formyl Met-tRNA and GTP are added. Initiation factors therefore control directly 30S–mRNA interaction independent of their effect on the binding of initiator tRNA.

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