Nature 222, 1087 - 1088 (14 June 1969); doi:10.1038/2221087a0

Increased Yields of Stomatitis Virus from Hamster Cells injected with Mycoplasma

STANLEY H. SINGER, RUTH L. KIRSCHSTEIN & MICHAEL F. BARILE

Laboratory of Pathology,
Laboratory of Bacterial Products, Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland 20014.

AT certain times, unexpectedly high yields of vesicular stomatitis virus (VSV) have been obtained from infected primary hamster embryo fibroblast (HEF) cell cultures,, which were later found to have been contaminated with mycoplasma. The work reported here indicates that this contamination can enhance VSV replication.

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