Nature 222, 1086 - 1087 (14 June 1969); doi:10.1038/2221086a0

Evidence for Genetic Expression of Integrated DNA in Lymphoma Cells

MARGARET FOX, B. W. FOX & S. R. AYAD^*

Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester 20.
^*Department of Biological Chemistry, University of Manchester.

EVIDENCE suggesting genetic transformation in mammalian cells has been reported^1–6. To test whether the integration of DNA⁷ is followed by its genetic expression, we have studied the transfer of resistance to 5-iodo-2'-deoxyuridine (IUdR) to lymphoma cells in culture.

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