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Letters to Nature
Nature 222, 482 - 483 (03 May 1969); doi:10.1038/222482a0

Long Biological Half-life of Vitamin D3 and its Polar Metabolites in Human Serum

E. B. MAWER, G. A. LUMB & S. W. STANBURY

Division of Metabolism, University Department of Medicine, The Royal Infirmary, Manchester.

RECENT estimates1,2, based on observations of radio-isotopically labelled cholecalciferol for up to 4 days, suggest that the biological half-life of vitamin D in human plasma does not exceed 50 h. Conversely, after administration of large amounts of vitamin D, the “vitamin D activity” of plasma assayed biologically falls slowly3,4, with a half-time that may exceed 3 months (unpublished work of G. A. L. and S. W. S.).

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References

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4. Antener, I., Bull. Soc. Suisse Chem. Clin., 1 (1960).
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6. Mawer, E. B., and Backhouse, J., Biochem. J. (in the press).
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