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Letters to Nature
Nature 221, 1251-1253 (29 March 1969) | doi:10.1038/2211251b0; Received 31 December 1968
Biological Activity of Synthetic Prostaglandins
P. W. RAMWELL, JANE E. SHAW, E. J. COREY & N. ANDERSEN
- Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545.
- Department of Chemistry, Harvard University, Boston, Massachusetts.
Abstract
THE total synthesis of prostaglandin E1 and prostaglandin F1a has recently been achieved by methods which also make available various derivatives and steroisomers of the prostaglandin series1,2. Biological studies on the synthetic prostaglandins, and certain unnatural synthetic stereoisomers, have been undertaken first to provide biological confirmation of the chemical synthesis and, second, to explore the metabolism and pharmacological activity of various stereoisomers in areas where the prostaglandins may be of clinical use. These include the regulation of gastric secretion3,4, blood platelet aggregation5, blood pressure, lipolysis, carbohydrate metabolism6 and corticosteroidogenesis7.
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