Nature 221, 1162 - 1164 (22 March 1969); doi:10.1038/2211162a0

Interactions of Dipyridamole and Adenosine on Platelet Aggregation

R. B. PHILP & J. P. V. LEMIEUX

Department of Pharmacology, University of Western Ontario, London, Canada.

DIPYRIDAMOLE (Persantine–Boehringer Ingelheim, Ltd), the coronary vasodilator, inhibits the entry of adenosine into red cells, and hence its breakdown^1,2—suggesting that this accounts for the pharmacological effect, for adenosine itself is a vasodilator³. The knowledge that adenosine is a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP)⁴ and of experimental thrombus formation^5,6 led Emmons et al. ^7,8 to confirm that dipyridamole has similar effects.

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