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Induction of Liver and Lung Tumours in Mice by 6-Aminochrysene administered during the First 3 Days of Life

Nature volume 221, pages 1063–1064 (1969)Cite this article

Abstract

IN 1953, Rudali and his colleagues1 reported the effects of 6-aminochrysene (Fig. 1) in mice and showed that this substance inhibited the growth of skin tumours, induced by 3-methylcholanthrene, and also of spontaneously occurring mammary carcinomas. Later, the same compound was shown to inhibit the induction of mammary carcinomas by 7,12-dimethylbenz(a)anthracene (DMBA) in Sprague–Dawley rats2. In a small clinical trial of 6-aminochrysene in patients with advanced mammary carcinoma3, objective regression was produced in two cases. In addition to its tumour-inhibiting properties, 6-aminochrysene reduces the number of circulating leucocytes (particularly lymphocytes) and causes atrophy of lymphoid structures4,5: these effects have already been exploited in the treatment of chronic myeloid leukaemia and of splenomegaly due to chronic malaria and other causes6,7.

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References

  1. Rudali, G., Buu-Hoi, N. P., and Lacassagne, A., CR Acad. Sci., 236, 2020 (1953).

    CAS  Google Scholar 

  2. Huggins, C., Grand, L., and Kukunishi, R., Proc. US Nat. Acad. Sci., 51, 737 (1964).

    Article  ADS  CAS  Google Scholar 

  3. Group Européen du Cancer du Sein, Europ. J. Cancer, 3, 75 (1967).

  4. Rudali, G., and Buu-Hoi, N. P., Rev. d'Hématol., 10, 28 (1955).

    CAS  Google Scholar 

  5. Hugonot, R., Proc. Third Intern. Cong. Chemother., 1 (1964).

  6. Buu-Hoi, N. P., Bui-Quoc-Huong, Tran-Lu-Y, and Chau-van-Tuong, Chemotherapia, 4, 1 (1962).

    Article  Google Scholar 

  7. Buu-Hoi, N. P., Bui-Quoc-Huong, and Tran-Lu-Y., Bull. Acad. Nat. Med., 146, 313 (1962).

    PubMed  CAS  Google Scholar 

  8. Lambelin, G., Mees, G., and Buu-Hoi, N. P., Arzneimittel-Forsch., 17, 1117 (1967).

    CAS  Google Scholar 

  9. Epstein, S. S., Andrea, J., Jaffs, H., Joshi, S., Falk, H., and Mantel, L., Nature, 215, 1388 (1967).

    Article  ADS  CAS  Google Scholar 

  10. Gorrod, J. W., Carter, R. L., and Roe, F. J. C., J. Nat. Cancer Inst., 41, 403 (1968).

    PubMed  CAS  Google Scholar 

  11. Roe, F. J. C., and Walters, M., Nature, 214, 299 (1967).

    Article  ADS  CAS  Google Scholar 

  12. Haddow, A., and Robinson, A. M., Proc. Roy. Soc., B, 122, 442 (1937).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Chester Beatty Research Institute, Fulham Road, London, SW3

    F. J. C. ROE, R. L. CARTER & SYLVIA ADAMTHWAITE

Authors
  1. F. J. C. ROE
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  2. R. L. CARTER
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  3. SYLVIA ADAMTHWAITE
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ROE, F., CARTER, R. & ADAMTHWAITE, S. Induction of Liver and Lung Tumours in Mice by 6-Aminochrysene administered during the First 3 Days of Life. Nature 221, 1063–1064 (1969). https://doi.org/10.1038/2211063a0

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