Abstract
IN normal human bile, cholesterol is maintained in micellar solution by bile salts and phospholipids. Precipitation of cholesterol occurs when the amount of bile salts and phospholipids falls relative to cholesterol1. There is evidence that in the presence of cholelithiasis there is a drop in the biliary bile salt–phospholipid/cholesterol ratio and an increase in the dihydroxy to trihydroxy bile salt ratio2. Phospholipids have been studied in normal bile3,4, but there is little information on phospholipid changes in the bile of subjects with gallstones. The present study has been undertaken to determine whether there are quantitative or qualitative changes in the phospholipids of human lithogenic gall bladder bile.
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ANDERSON, F., BOUCHIER, I. Phospholipids in Human Lithogenic Gall Bladder Bile. Nature 221, 372–373 (1969). https://doi.org/10.1038/221372a0
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DOI: https://doi.org/10.1038/221372a0
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