Abstract
PLATELETS are aggregated in vivo and in vitro by ADP1,2. Several agents such as thrombin, collagen and certain fatty acids cause aggregation by releasing ADP3. We reported that ADP, 5-hydroxytryptamine and adrenaline do not bring about aggregation of nucleated thrombocytes of chicken (Gallus domesticus), turtle (Pseudemys scripta elegans), alligator (Alligator mississippensis) and smooth dogfish (Mustelus canis), whereas thrombin does4,5. Thrombin seems to aggregate platelets by releasing ADP, and so we wondered whether ADP has any role in the aggregation of turtle thrombocytes by thrombin. We were also interested in the ability of thrombin and collagen to cause release of adenine nucleotides from thrombocytes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gaarder, A., Jonsen, J., Laland, S., Hellem, A., and Owren, P. A., Nature, 192, 531 (1961).
Born, G. V. R., Nature, 197, 974 (1963).
Haslam, R. J., in Physiology of Hemostasis and Thrombosis (edit. by Johnson, S. A., and Seegers, W. H.), 88 (Thomas, Springfield, 1967).
Belamarich, F. A., Fusari, M. H., Shepro, D., and Kien, M., Nature, 212, 1579 (1966).
Belamarich, F. A., Shepro, D., Kien, M., and Fulton, G. P., Fed. Proc., 26, 760 (1967).
Holmsen, H., Holmsen, I., and Bernhardsen, A., Anal. Biochem., 17, 456 (1966).
Haslam, R. J., Nature, 202, 765 (1964).
Hovig, T., Thromb. Diath. Haemorrh., 9, 264 (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BELAMARICH, F., SHEPRO, D. & KIEN, M. ADP is not Involved in Thrombin-induced Aggregation of Thrombocytes of a Non-mammalian Vertebrate. Nature 220, 509–510 (1968). https://doi.org/10.1038/220509a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/220509a0
This article is cited by
-
Ultrastructural alterations in thrombocytes of the snake Waglerophis merremii after Activation by ADP
Comparative Haematology International (1994)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
