Abstract
The haemoglobin molecule is insensitive to replacements of most amino-acid residues on its surface, but extremely sensitive to even quite small alterations of internal non-polar contacts, especially those near the haems. Replacements at the contacts between α and β-subunits affect respiratory function.
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PERUTZ, M., LEHMANN, H. Molecular Pathology of Human Haemoglobin. Nature 219, 902–909 (1968). https://doi.org/10.1038/219902a0
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DOI: https://doi.org/10.1038/219902a0
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