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Skeletal Deposition and Toxicity of Methacycline

Nature volume 219, pages 624–625 (1968)Cite this article

Abstract

THE first investigation1 of the skeletal deposition of tetracyclines was published by André in 1956. Later investigations by fluorescence microscopy showed that the tetracyclines are fixed to mineralizing tissues in association with the ossification process2–4, endochondral calcification5–8 and the mineralization of enamel and dentine9,10. Even in fairly small doses the tetracyclines have a noxious effect on the mineralization process8,11,12.

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Authors and Affiliations

  1. Department of Histology and Department of Orthopaedics, University of Lund, Sweden

    L. I. HANSSON, A. STENSTRØM & K.-G. THORNGREN

Authors
  1. L. I. HANSSON
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  2. A. STENSTRØM
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  3. K.-G. THORNGREN
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HANSSON, L., STENSTRØM, A. & THORNGREN, KG. Skeletal Deposition and Toxicity of Methacycline. Nature 219, 624–625 (1968). https://doi.org/10.1038/219624a0

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