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Human Circadian Rhythms and the 48 Hour Day

Abstract

A COMMON approach to the understanding of human circadian rhythms is to study their modifiability. Attempts to replace the 24 h sleep–wakefulness rhythm in man by cycles of slightly altered length (for example, 21 or 27 h) have had some success1,2. Attempts to produce sleeping–waking rhythms which are a multiple of the natural cycle length such as 12 or 48 h have not, however, been very successful2,3; the reasons for this are not yet clear.

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References

  1. Lewis, P. R., and Lobban, M. C., Quart. J. Exp. Physiol., 42, 356 (1957).

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  2. Kleitman, N., Sleep and Wakefulness, 175 (Univ. Chicago Press, 1963).

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  3. Dement, W., Science, 131, 1705 (1960).

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MEDDIS, R. Human Circadian Rhythms and the 48 Hour Day. Nature 218, 964–965 (1968). https://doi.org/10.1038/218964a0

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