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Letters to Nature
Nature 217, 270 - 271 (20 January 1968); doi:10.1038/217270a0

Sialotonin: Vasopressor Substance in Cat Submaxillary Saliva

C. MORIWAKI, SUSANNE BEILENSON & M. SCHACHTER

Department of Physiology, University of Alberta, Edmonton, Alberta, Canada.

THE potent vasodepressor effect of cat's submaxillary saliva after intravenous injection into the cat was first noted by Secker1,2. After some controversy about the alleged similarity of this substance to acetylcholine3–5, it is now clear that it is a glycoprotein, that is salivary kallikrein6,7.

  1. Secker, J. , J. Physiol., 81, 81 (1934). | ChemPort |
  2. Secker, J. , J. Physiol., 82, 293 (1934). | ChemPort |
  3. Feldberg, W. , and Guimarais, J. A. , J. Physiol., 85, 15 (1935). | ChemPort |
  4. Gibbs, O. S. , J. Physiol., 84, 33 (1935). | ChemPort |
  5. Larson, P. S. , J. Pharmacol. and Exp. Therap., 54, 341 (1935). | ChemPort |
  6. Frey, E. K. , Kraut, H. , and Werle, E. , Kallikrein (Padutin), (Ferninand Enke, Stuttgart, 1950, 1968).
  7. Schachter, M. , Ann. Rev. Pharmacol., 4, 281 (1964). | Article | ISI | ChemPort |
  8. Werle, E. , and von Roden, P. , Biochem. Z., 301, 328 (1939). | ChemPort |
  9. Beilenson, S. , Schachter, M. , and Smaje, L. H. , J. Physiol., 177, 61P (1965).



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